Phage therapy, long overshadowed by chemical antibiotics, is garnering renewed interest in
Western medicine. This stems from the rise in frequency of multi-drug-resistant bacterial …

Bacteriophage (phage) therapy, ie, the use of viruses that infect bacteria as antimicrobial
agents, is a promising alternative to conventional antibiotics. Indeed, resistance to antibiotics …

For a bacteriophage to be useful for phage therapy it must be both isolated from the
environment and shown to have certain characteristics beyond just killing strains of the …

The widespread use of antibiotics in the past 80 years has saved millions of human lives,
facilitated technological progress and killed incalculable numbers of microbes, both …

The adsorption of bacteriophages (phages) onto host cells is, in all but a few rare cases, a
sine qua non condition for the onset of the infection process. Understanding the …

Antibiotic resistance is a major public health challenge worldwide, whose implications for
global health might be devastating if novel antibacterial strategies are not quickly …

Viruses of bacteria, known as bacteriophages or phages, were discovered nearly 100 years
ago. Their potential as antibacterial agents was appreciated almost immediately, with the …

Highlights•Phages need to attach to a receptor on the bacterial surface to initiate infection.•It
is not common practice to identify these receptors before phage therapy use.•Identifying …

Antivirulence drugs are a new type of therapeutic drug that target virulence factors,
potentially revitalising the drug-development pipeline with new targets. As antivirulence …

Bacteria that cause life-threatening infections in humans are becoming increasingly difficult
to treat. In some instances, this is due to intrinsic and acquired antibiotic resistance …