Effective management of procedural and postoperative pain in neonates is required to
minimize acute physiological and behavioral distress and may also improve acute and long …

Determining the right dose for drugs used to treat neonates is critically important. Neonates
have significant differences in physiology affecting drug absorption, distribution, metabolism …

Background Neonates and infants requiring anaesthesia are at risk of physiological
instability and complications, but triggers for peri-anaesthetic interventions and associations …

Effective and safe drug administration in neonates should be based on integrated
knowledge on the evolving physiological characteristics of the infant who will receive the …

Propofol is a widely used general anesthetic. A growing body of data suggests that perinatal
exposure to general anesthetics can result in long-term deleterious effects on brain function …

Neonates undergoing surgery are at higher risk than older children for anesthesia-related
adverse events. During the perioperative period, the maintenance of optimal hemodynamics …

Ketamine is a widely-used anesthetic in the field of pediatrics and obstetrics. Multiple studies
have revealed that ketamine causes neurotoxicity in developing animals. However, further …

Adverse drug reactions (ADRs) are major clinical problems, particularly in special
populations such as pediatric patients. Indeed, ADRs may be caused by a plethora of …

Background The amplitude-integrated EEG (aEEG) is a widely used monitoring tool in
neonatology/pediatric intensive care. It takes into account the amplitudes, but not the …

Aims The objectives of this study were to develop a population pharmacokinetic (PopPK)
model for tacrolimus in paediatric liver transplant patients and determine optimal sampling …