The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics

L Qian, X Lin, X Gao, RU Khan, JY Liao, S Du… - Chemical …, 2023 - ACS Publications
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

[HTML][HTML] Functionalized liposomes for targeted breast cancer drug delivery

J Nel, K Elkhoury, É Velot, A Bianchi, S Acherar… - Bioactive materials, 2023 - Elsevier
Despite the exceptional progress in breast cancer pathogenesis, prognosis, diagnosis, and
treatment strategies, it remains a prominent cause of female mortality worldwide …

[HTML][HTML] Recent advancements in polymer/liposome assembly for drug delivery: From surface modifications to hybrid vesicles

V De Leo, F Milano, A Agostiano, L Catucci - Polymers, 2021 - mdpi.com
Liposomes are consolidated and attractive biomimetic nanocarriers widely used in the field
of drug delivery. The structural versatility of liposomes has been exploited for the …

[HTML][HTML] Recent advances in sensing the inter-biomolecular interactions at the nanoscale–A comprehensive review of AFM-based force spectroscopy

A Lostao, KS Lim, MC Pallarés, A Ptak… - International journal of …, 2023 - Elsevier
Biomolecular interactions underpin most processes inside the cell. Hence, a precise and
quantitative understanding of molecular association and dissociation events is crucial, not …

Innovative nanomaterials for cancer diagnosis, imaging, and therapy: Drug delivery applications

M Pourmadadi, MM Eshaghi, S Ostovar… - Journal of Drug Delivery …, 2023 - Elsevier
The emergence of nanomedicine drugs as a result of the fast advancement of
nanotechnology offers enormous potential for improving cancer treatment strategies. The …

Injectable amphipathic artesunate prodrug‐hydrogel microsphere as gene/drug nano‐microplex for rheumatoid arthritis therapy

C Li, Y Du, H Lv, J Zhang, P Zhuang… - Advanced Functional …, 2022 - Wiley Online Library
Artemisinin and its derivatives (artemisinins) are first‐line chemotherapeutic agents of lethal
malaria, which also showed tremendous value in many other diseases including chronic …

[HTML][HTML] Organically derived exosomes as carriers of anticancer drugs and imaging agents for cancer treatment

A Srivastava, S Rathore, A Munshi… - Seminars in cancer biology, 2022 - Elsevier
Extracellular vesicles (EVs), is the umbrella term used for different types of vesicles
produced by the cells, among which exosomes form the largest group. Exosomes perform …

[HTML][HTML] Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual …

C Hu, Y Song, Y Zhang, S He, X Liu, X Yang… - … Pharmaceutica Sinica B, 2023 - Elsevier
Intelligent responsive drug delivery system opens up new avenues for realizing safer and
more effective combination immunotherapy. Herein, a kind of tumor cascade-targeted …

[HTML][HTML] Nanoparticles advanced from preclinical studies to clinical trials for lung cancer therapy

Y Liu, W Cheng, HY Xin, R Liu, Q Wang, W Cai… - Cancer …, 2023 - Springer
Lung cancer is the leading cause of cancer mortality. As a heterogeneous disease, it has
different subtypes and various treatment modalities. In addition to conventional surgery …

[HTML][HTML] Research progress in inducing immunogenic cell death of tumor cells

D Xie, Q Wang, G Wu - Frontiers in immunology, 2022 - frontiersin.org
Immunogenic cell death (ICD) is a regulated cell death (RCD) pathway. In response to
physical and chemical signals, tumor cells activate specific signaling pathways that stimulate …