[HTML][HTML] Ion channels as therapeutic targets in high grade gliomas

M Griffin, R Khan, S Basu, S Smith - Cancers, 2020 - mdpi.com
Simple Summary Glioblastoma multiforme is an aggressive grade IV lethal brain tumour with
a median survival of 14 months. Despite surgery to remove the tumour, and subsequent …

[HTML][HTML] Repurposing antipsychotics for cancer treatment

N Vlachos, M Lampros, S Voulgaris, GA Alexiou - Biomedicines, 2021 - mdpi.com
Cancer is a leading cause of death worldwide, with approximately 19 million new cases
each year. Lately, several novel chemotherapeutic drugs have been introduced, efficiently …

Penfluridol represses integrin expression in breast cancer through induction of reactive oxygen species and downregulation of Sp transcription factors

E Hedrick, X Li, S Safe - Molecular cancer therapeutics, 2017 - AACR
It was recently demonstrated the penfluridol inhibited breast tumor growth and metastasis
and this was associated with downregulation of α6-and β4-integrins. In this study, we …

[HTML][HTML] Penfluridol suppresses glioblastoma tumor growth by Akt-mediated inhibition of GLI1

A Ranjan, SK Srivastava - Oncotarget, 2017 - ncbi.nlm.nih.gov
Glioblastoma (GBM) is the most common brain tumor with poor survival rate. Our results
show that penfluridol, an antipsychotic drug significantly reduced the survival of ten adult …

[HTML][HTML] Pre-clinical study evaluating novel protein phosphatase 2A activators as therapeutics for neuroblastoma

LV Bownes, R Marayati, CH Quinn, AM Beierle… - Cancers, 2022 - mdpi.com
Simple Summary Despite significant advancements in neuroblastoma therapy, over half of
the children with high-risk neuroblastoma will suffer disease relapse. Protein phosphatase …

[HTML][HTML] In silico analysis identified miRNA‑based therapeutic agents against glioblastoma multiforme

DD Xiong, WQ Xu, RQ He, YW Dang… - Oncology …, 2019 - spandidos-publications.com
MicroRNAs (miRNAs or miRs) contribute to the development of various malignant
neoplasms, including glioblastoma multiforme (GBM). The present study aimed to explore …

[HTML][HTML] Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute …

SY Wu, YC Wen, CC Ku, YC Yang, JM Chow… - Journal of Biomedical …, 2019 - Springer
Background Chemotherapy is the main treatment for acute myeloid leukemia (AML), but the
cure rates for AML patients remain low, and the notorious adverse effects of …

[HTML][HTML] Human pancreatic cancer patients with Epithelial-to-Mesenchymal Transition and an aggressive phenotype show a disturbed balance in Protein Phosphatase …

J Van Pelt, B Meeusen, R Derua, L Guffens… - Journal of Translational …, 2023 - Springer
Background Pancreatic ductal adenocarcinoma (PDAC) has a low survival, its incidence is
rising and little therapeutic improvements are expected in the near future. It has been …

Drug repurposing: Antimicrobial and antibiofilm effects of penfluridol against Enterococcus faecalis

X Zeng, P She, L Zhou, S Li, Z Hussain… - …, 2021 - Wiley Online Library
The bacterium Enterococcus faecalis has increasingly attracted global attention as an
important opportunistic pathogen due to its ability to form biofilms that are known to increase …

[HTML][HTML] KLF14 regulates the growth of hepatocellular carcinoma cells via its modulation of iron homeostasis through the repression of iron-responsive element …

H Zhou, J Chen, M Fan, H Cai, Y Dong, Y Qiu… - Journal of Experimental …, 2023 - Springer
Background Hepatocellular carcinoma (HCC) is a multifactor-driven malignant tumor with
rapid progression, which causes the difficulty to substantially improve the prognosis of HCC …