[HTML][HTML] Ion channels as therapeutic targets in high grade gliomas
M Griffin, R Khan, S Basu, S Smith - Cancers, 2020 - mdpi.com
Simple Summary Glioblastoma multiforme is an aggressive grade IV lethal brain tumour with
a median survival of 14 months. Despite surgery to remove the tumour, and subsequent …
a median survival of 14 months. Despite surgery to remove the tumour, and subsequent …
[HTML][HTML] Repurposing antipsychotics for cancer treatment
N Vlachos, M Lampros, S Voulgaris, GA Alexiou - Biomedicines, 2021 - mdpi.com
Cancer is a leading cause of death worldwide, with approximately 19 million new cases
each year. Lately, several novel chemotherapeutic drugs have been introduced, efficiently …
each year. Lately, several novel chemotherapeutic drugs have been introduced, efficiently …
Penfluridol represses integrin expression in breast cancer through induction of reactive oxygen species and downregulation of Sp transcription factors
It was recently demonstrated the penfluridol inhibited breast tumor growth and metastasis
and this was associated with downregulation of α6-and β4-integrins. In this study, we …
and this was associated with downregulation of α6-and β4-integrins. In this study, we …
[HTML][HTML] Penfluridol suppresses glioblastoma tumor growth by Akt-mediated inhibition of GLI1
A Ranjan, SK Srivastava - Oncotarget, 2017 - ncbi.nlm.nih.gov
Glioblastoma (GBM) is the most common brain tumor with poor survival rate. Our results
show that penfluridol, an antipsychotic drug significantly reduced the survival of ten adult …
show that penfluridol, an antipsychotic drug significantly reduced the survival of ten adult …
[HTML][HTML] Pre-clinical study evaluating novel protein phosphatase 2A activators as therapeutics for neuroblastoma
LV Bownes, R Marayati, CH Quinn, AM Beierle… - Cancers, 2022 - mdpi.com
Simple Summary Despite significant advancements in neuroblastoma therapy, over half of
the children with high-risk neuroblastoma will suffer disease relapse. Protein phosphatase …
the children with high-risk neuroblastoma will suffer disease relapse. Protein phosphatase …
[HTML][HTML] In silico analysis identified miRNA‑based therapeutic agents against glioblastoma multiforme
DD Xiong, WQ Xu, RQ He, YW Dang… - Oncology …, 2019 - spandidos-publications.com
MicroRNAs (miRNAs or miRs) contribute to the development of various malignant
neoplasms, including glioblastoma multiforme (GBM). The present study aimed to explore …
neoplasms, including glioblastoma multiforme (GBM). The present study aimed to explore …
[HTML][HTML] Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute …
SY Wu, YC Wen, CC Ku, YC Yang, JM Chow… - Journal of Biomedical …, 2019 - Springer
Background Chemotherapy is the main treatment for acute myeloid leukemia (AML), but the
cure rates for AML patients remain low, and the notorious adverse effects of …
cure rates for AML patients remain low, and the notorious adverse effects of …
[HTML][HTML] Human pancreatic cancer patients with Epithelial-to-Mesenchymal Transition and an aggressive phenotype show a disturbed balance in Protein Phosphatase …
J Van Pelt, B Meeusen, R Derua, L Guffens… - Journal of Translational …, 2023 - Springer
Background Pancreatic ductal adenocarcinoma (PDAC) has a low survival, its incidence is
rising and little therapeutic improvements are expected in the near future. It has been …
rising and little therapeutic improvements are expected in the near future. It has been …
Drug repurposing: Antimicrobial and antibiofilm effects of penfluridol against Enterococcus faecalis
X Zeng, P She, L Zhou, S Li, Z Hussain… - …, 2021 - Wiley Online Library
The bacterium Enterococcus faecalis has increasingly attracted global attention as an
important opportunistic pathogen due to its ability to form biofilms that are known to increase …
important opportunistic pathogen due to its ability to form biofilms that are known to increase …
[HTML][HTML] KLF14 regulates the growth of hepatocellular carcinoma cells via its modulation of iron homeostasis through the repression of iron-responsive element …
H Zhou, J Chen, M Fan, H Cai, Y Dong, Y Qiu… - Journal of Experimental …, 2023 - Springer
Background Hepatocellular carcinoma (HCC) is a multifactor-driven malignant tumor with
rapid progression, which causes the difficulty to substantially improve the prognosis of HCC …
rapid progression, which causes the difficulty to substantially improve the prognosis of HCC …