Background Glutamine metabolism plays a key role in various biological processes of tumor.
Glutaminase (GLS) is involved in Glutamine metabolism and plays a conserved regulatory …

Reversible protein phosphorylation is perhaps the most abundant mechanism of
communication through which cells regulate proteins to guide cellular processes in …

The connectivity map (CMAP) database is established initially to connect biology, chemistry,
and clinical conditions, which helps to discover the connections between disease-gene …

Abstract Gastro-intestinal (GI) malignancies, including gastric, colorectal, and pancreatic
cancers, have maintained their high overall mortality due to a lack of prognostic and …

Glioblastoma multiforme (GBM) is a lethal brain cancer with an average survival of 14-15
months with maximal treatment. High grade gliomas (HGG) form a leading cause of CNS …

Integrins are known to play an important role in activating multiple intracellular pathways,
one of which is focal adhesion kinase (FAK). Phosphorylation of FAK can lead to the …

Background: Head and neck squamous cell carcinoma (HNSCC) is one of the most common
cancers occupying the sixth position worldwide. PI3k/Akt signaling pathway plays a …

Aluminum (Al) is present on earth surface has different chemical forms. It is a toxic metal and
it may cause different disorders such as osteomalacia, microcytic anemia, Alzheimer and …

Background: Chemotherapy is the main treatment for acute myeloid leukemia (AML), but the
cure rates for AML patients remain low, and the notorious adverse effects of …

Protein kinases have gained acceptance as therapeutic phosphatase 2A (PP2A) is
composed of ABC subunits and targets and have become a major focus of drug …