Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
The neurotransmitter puzzle of Alzheimer's: Dissecting mechanisms and exploring therapeutic horizons
M Sharma, P Pal, SK Gupta - Brain Research, 2024 - Elsevier
Alzheimer's Disease (AD) represents a complex interplay of neurological pathways and
molecular mechanisms, with significant impacts on patients' lives. This review synthesizes …
molecular mechanisms, with significant impacts on patients' lives. This review synthesizes …
LRP1 and RAGE Genes Transporting Amyloid and Tau Protein in the Hippocampal CA3 Area in an Ischemic Model of Alzheimer's Disease with 2-Year Survival
R Pluta, J Kocki, J Bogucki, A Bogucka-Kocka… - Cells, 2023 - mdpi.com
Explaining changes at the gene level that occur during neurodegeneration in the CA3 area
is crucial from the point of view of memory impairment and the development of post-ischemic …
is crucial from the point of view of memory impairment and the development of post-ischemic …
Identifying underlying patterns in Alzheimer's disease trajectory: a deep learning approach and Mendelian randomization analysis
Background Alzheimer's disease (AD) is a heterogeneously progressive neurodegeneration
disorder with varied rates of deterioration, either between subjects or within different stages …
disorder with varied rates of deterioration, either between subjects or within different stages …
Methamphetamine exposure drives cell cycle exit and aberrant differentiation in rat hippocampal-derived neurospheres
S Wang, L Wang, Q Bu, Q Wei, L Jiang, Y Dai… - Frontiers in …, 2023 - frontiersin.org
Introduction: Methamphetamine (METH) abuse by pregnant drug addicts causes toxic effects
on fetal neurodevelopment; however, the mechanism underlying such effect of METH is …
on fetal neurodevelopment; however, the mechanism underlying such effect of METH is …
Alpha-, Beta-, and Gamma-Secretase, Amyloid Precursor Protein, and Tau Protein Genes in the Hippocampal CA3 Subfield in an Ischemic Model of Alzheimer's …
J Kocki, B Miziak, J Bogucki… - Journal of …, 2024 - content.iospress.com
Background: Understanding the phenomena underlying the non-selective susceptibility to
ischemia of pyramidal neurons in the CA3 is important from the point of view of elucidating …
ischemia of pyramidal neurons in the CA3 is important from the point of view of elucidating …
Zexieyin formula alleviates alzheimer's disease via post-synaptic CaMKII modulating AMPA receptor: involved in promoting neurogenesis to strengthen synaptic …
Y Sun, H Zhang, R Liu, Y Wang, X Zhang, R Huang… - Phytomedicine, 2024 - Elsevier
Background Alzheimer's disease (AD) is a serious neurodegenerative disease and brings a
serious burden to society and families. Due to lack of effective drugs for the treatment of AD …
serious burden to society and families. Due to lack of effective drugs for the treatment of AD …
[HTML][HTML] Omaveloxolone ameliorates cognitive dysfunction in APP/PS1 mice by stabilizing the STAT3 pathway
X Cui, S Zong, W Song, C Wang, Y Liu, L Zhang, P Xia… - Life Sciences, 2023 - Elsevier
Aims To determine the availability and the potential molecular mechanisms underlying the
therapeutic effect of omaveloxolone (RTA408) on Alzheimer's Disease (AD). Materials and …
therapeutic effect of omaveloxolone (RTA408) on Alzheimer's Disease (AD). Materials and …
记忆辨别力受老化影响的认知神经机制及其应用
曾庆贺, 崔晓宇, 唐为, 李娟 - 心理科学进展, 2024 - journal.psych.ac.cn
记忆辨别力是对相似的记忆经验进行准确辨别的能力, 其依赖于名为模式分离的神经计算机制,
在人类被试中, 通常使用记忆相似性任务对其进行测量与研究. 在老化过程中 …
在人类被试中, 通常使用记忆相似性任务对其进行测量与研究. 在老化过程中 …
The cognitive neural mechanisms of age-related decline in mnemonic discrimination and its application
Q ZENG, X CUI, W TANG, J LI - Advances in Psychological …, 2024 - journal.psych.ac.cn
Mnemonic discrimination (MD) refers to the ability to accurately distinguish similar memory
experiences. Currently, mnemonic similarity task (MST) is commonly employed to measure …
experiences. Currently, mnemonic similarity task (MST) is commonly employed to measure …