Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids,
RNA, and DNA. They are derived from endocytic membranes and can transfer signals to …

Tumors are not isolated entities, but complex systemic networks involving cell-cell
communication between transformed and non-transformed cells. The milieu created by …

Malignancy affects the hemostatic system and the hemostatic system affects malignancy. In
cancer patients there are a number of coagulation abnormalities which provide the …

Venous thromboembolism occurs commonly in patients with cancer. The pathogenetic
mechanisms of thrombosis involve a complex interaction between tumour cells, the …

Cancer patients are at high risk for venous thromboembolism (VTE). Laboratory parameters
with a predictive value for VTE could help stratify patients into high-or low-risk groups. The …

During wound healing and angiogenesis, fibrin serves as a provisional extracellular matrix.
We use a model system of fibroblasts embedded in fibrin gels to study how cell-mediated …

Patients with hematologic malignancies are at high risk of thrombotic or hemorrhagic
complications. The incidence of these events is greatly variable and is influenced by many …

Hepatocellular carcinoma (HCC) is a primary liver cancer that usually develops in the setting
of chronic inflammation and liver damage. The hepatic microenvironment plays a crucial role …

Thrombosis is a major cause of morbidity and mortality in cancer patients. The pathogenesis
of blood coagulation activation in oncological patients is complex and involves both clinical …

Extracellular vesicles (EVs) are a heterogeneous group of structures which can be classified
into smaller in size and relatively homogenous exosomes (EXSMs)—spherical fragments of …