Risk of colorectal cancer in inflammatory bowel diseases

MS Nadeem, V Kumar, FA Al-Abbasi, MA Kamal… - Seminars in cancer …, 2020 - Elsevier
Inflammatory bowel diseases (IBDs) are chronic problems of gastrointestinal tract (GIT) with
poorly understood aetiology. Patients with any of the two common entities, Crohn's disease …

[HTML][HTML] Glutamine metabolism in macrophages: a novel target for obesity/type 2 diabetes

W Ren, Y Xia, S Chen, G Wu, FW Bazer, B Zhou… - Advances in …, 2019 - Elsevier
Obesity is a nutritional disorder resulting from a chronic imbalance between energy intake
and expenditure. This disease is characterized by inflammation in multiple cell types …

Tiliroside Ameliorates Ulcerative Colitis by Restoring the M1/M2 Macrophage Balance via the HIF-1α/glycolysis Pathway

H Zhuang, Q Lv, C Zhong, Y Cui, L He… - Frontiers in …, 2021 - frontiersin.org
Macrophages polarized to different phenotypes critically contribute to colitis development by
coordinating inflammatory and anti-inflammatory processes. Herein, targeting the balance …

Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon

JO Múnera, DO Kechele, C Bouffi, N Qu, R Jing… - Cell stem cell, 2023 - cell.com
Most organs have tissue-resident immune cells. Human organoids lack these immune cells,
which limits their utility in modeling many normal and disease processes. Here, we describe …

Immunoregulation of macrophages by dynamic ligand presentation via ligand–cation coordination

H Kang, B Yang, K Zhang, Q Pan, W Yuan, G Li… - Nature …, 2019 - nature.com
Macrophages regulate host responses to implants through their dynamic adhesion, release,
and activation. Herein, we employ bisphosphonate (BP)-coated gold nanoparticle template …

Macrophage polarization in inflammatory bowel disease

K Zhang, J Guo, W Yan, L Xu - Cell Communication and Signaling, 2023 - Springer
The growing prevalence of inflammatory bowel disease (IBD) has encouraged research
efforts, which have contributed to gradual improvements in our understanding of IBD …

Structural differences of polysaccharides from Astragalus before and after honey processing and their effects on colitis mice

J Wu, C Li, L Bai, J Wu, R Bo, M Ye, L Huang… - International Journal of …, 2021 - Elsevier
Honey-processed Astragalus is a dosage form of Radix Astragali processed with honey,
which exhibits better efficacy of tonifying Qi than the raw product. Polysaccharides are its …

Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in situ

B Koscsó, S Kurapati, RR Rodrigues, J Nedjic… - Science …, 2020 - science.org
Intestinal mononuclear phagocytes (MPs) are composed of heterogeneous dendritic cell
(DC) and macrophage subsets necessary for the initiation of immune response and control …

Protocadherin 20 maintains intestinal barrier function to protect against Crohn's disease by targeting ATF6

S Huang, Z Xie, J Han, H Wang, G Yang, M Li, G Zhou… - Genome Biology, 2023 - Springer
Background Intestinal barrier dysfunction plays a central role in the pathological onset of
Crohn's disease. We identify the cadherin superfamily member protocadherin 20 (PCDH20) …

Understanding immunoactinopathies: A decade of research on WAS gene defects

RC Vieira, LG Pinho… - Pediatric Allergy and …, 2023 - Wiley Online Library
Immunoactinopathies caused by mutations in actin‐related proteins are a growing group of
inborn errors of immunity (IEI). Immunoactinopathies are caused by a dysregulated actin …