The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML

D Vetrie, GV Helgason, M Copland - Nature Reviews Cancer, 2020 - nature.com
For two decades, leukaemia stem cells (LSCs) in chronic myeloid leukaemia (CML) and
acute myeloid leukaemia (AML) have been advanced paradigms for the cancer stem cell …

The chronic myeloid leukemia stem cell: stemming the tide of persistence

TL Holyoake, D Vetrie - Blood, The Journal of the American …, 2017 - ashpublications.org
Chronic myeloid leukemia (CML) is caused by the acquisition of the tyrosine kinase BCR-
ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self …

Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use

GP Fadini, D Losordo, S Dimmeler - Circulation research, 2012 - Am Heart Assoc
Diverse subsets of endothelial progenitor cells (EPCs) are used for the treatment of ischemic
diseases in clinical trials, and circulating EPCs levels are considered as biomarkers for …

Transdifferentiation of glioblastoma cells into vascular endothelial cells

Y Soda, T Marumoto… - Proceedings of the …, 2011 - National Acad Sciences
Glioblastoma (GBM) is the most malignant brain tumor and is highly resistant to intensive
combination therapies and anti-VEGF therapies. To assess the resistance mechanism to anti …

Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals

MC Yoder, LE Mead, D Prater, TR Krier, KN Mroueh… - Blood, 2007 - ashpublications.org
The limited vessel-forming capacity of infused endothelial progenitor cells (EPCs) into
patients with cardiovascular dysfunction may be related to a misunderstanding of the …

Mobilization of endothelial progenitor cells in patients with acute myocardial infarction

S Shintani, T Murohara, H Ikeda, T Ueno, T Honma… - Circulation, 2001 - Am Heart Assoc
Background—Endothelial progenitor cells (EPCs) circulate in adult peripheral blood (PB)
and contribute to neovascularization. However, little is known regarding whether EPCs and …

Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?

E Passegué, CHM Jamieson… - Proceedings of the …, 2003 - National Acad Sciences
Leukemia can be viewed as a newly formed, abnormal hematopoietic tissue initiated by a
few leukemic stem cells (LSCs) that undergo an aberrant and poorly regulated process of …

[HTML][HTML] Leukemia stem cells and microenvironment: biology and therapeutic targeting

MY Konopleva, CT Jordan - Journal of clinical oncology, 2011 - ncbi.nlm.nih.gov
Acute myelogenous leukemia is propagated by a subpopulation of leukemia stem cells
(LSCs). In this article, we review both the intrinsic and extrinsic components that are known …

Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice

Y Hu, Z Zhang, E Torsney, AR Afzal… - The Journal of …, 2004 - Am Soc Clin Investig
Recent evidence indicates that vascular progenitor cells may be the source of smooth
muscle cells (SMCs) that accumulate in atherosclerotic lesions, but the origin of these …

Endothelial progenitor cells for postnatal vasculogenesis

T Asahara, A Kawamoto - American Journal of Physiology …, 2004 - journals.physiology.org
In the past decade, researchers have defined committed stem or progenitor cells from
various tissues, including bone marrow, peripheral blood, brain, liver, and reproductive …