[HTML][HTML] Molecular biological and clinical understanding of the pathophysiology and treatments of hyperuricemia and its association with metabolic syndrome …

H Yanai, H Adachi, M Hakoshima… - International journal of …, 2021 - mdpi.com
Uric acid (UA) is synthesized mainly in the liver, intestines, and vascular endothelium as the
end product of an exogenous purine from food and endogenously from damaged, dying …

[HTML][HTML] Physiology of hyperuricemia and urate-lowering treatments

CL Benn, P Dua, R Gurrell, P Loudon, A Pike… - Frontiers in …, 2018 - frontiersin.org
Gout is the most common form of inflammatory arthritis and is a multifactorial disease
typically characterized by hyperuricemia and monosodium urate crystal deposition …

Research advances in the mechanisms of hyperuricemia‐induced renal injury

H Su, C Yang, D Liang, H Liu - BioMed Research International, 2020 - Wiley Online Library
Uric acid is the end product of purine metabolism in humans, and its excessive accumulation
leads to hyperuricemia and urate crystal deposition in tissues including joints and kidneys …

[HTML][HTML] Inulin supplementation ameliorates hyperuricemia and modulates gut microbiota in Uox-knockout mice

Y Guo, Y Yu, H Li, X Ding, X Li, X Jing, J Chen… - European journal of …, 2021 - Springer
Purpose Inulin is a type of fermentable dietary fiber, which is non-digestible, and can
improve metabolic function by modulating intestinal microbiota. This study aimed to evaluate …

[HTML][HTML] Excess uric acid induces gouty nephropathy through crystal formation: a review of recent insights

Y Mei, B Dong, Z Geng, L Xu - Frontiers in Endocrinology, 2022 - frontiersin.org
Uric acid (UA) is the final product of purine metabolism in the human body, and impaired
purine metabolism can increase the uric acid in serum, finally resulting in hyperuricemia …

Demographic, regional and temporal trends of hyperuricemia epidemics in mainland China from 2000 to 2019: a systematic review and meta-analysis

Y Li, Z Shen, B Zhu, H Zhang, X Zhang… - Global health action, 2021 - Taylor & Francis
Background Hyperuricemia (HUA) is becoming a global public health problem and
associated with multiple diseases. Objective We conducted a systematic review to …

[HTML][HTML] Advanced hematite nanomaterials for newly emerging applications

H Wan, L Hu, X Liu, Y Zhang, G Chen, N Zhang… - Chemical …, 2023 - pubs.rsc.org
Because of the combined merits of rich physicochemical properties, abundance, low toxicity,
etc., hematite (α-Fe2O3), one of the most chemically stable compounds based on the …

[HTML][HTML] Renal effects of uric acid: hyperuricemia and hypouricemia

JH Park, YI Jo, JH Lee - The Korean journal of internal medicine, 2020 - ncbi.nlm.nih.gov
The prevalence of chronic kidney disease (CKD) is increasing worldwide. Although
hyperuricemia has been associated with CKD in many studies, it remains controversial …

Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency

M Wu, Y Ma, X Chen, N Liang, S Qu… - Disease models & …, 2021 - journals.biologists.com
Epidemiological research has shown that elevated serum urate concentration is a risk factor
for the development of kidney disease; however, the mechanisms underlying this process …

[HTML][HTML] Risk factors for the development of hyperuricemia: A STROBE-compliant cross-sectional and longitudinal study

Q Ni, X Lu, C Chen, H Du, R Zhang - Medicine, 2019 - journals.lww.com
Risk factors for the development of hyperuricemia: A STROBE-... : Medicine Risk factors for the
development of hyperuricemia: A STROBE-compliant cross-sectional and longitudinal study …