Female subfertility

CM Farquhar, S Bhattacharya, S Repping… - Nature reviews Disease …, 2019 - nature.com
Subfertility is common and affects one in six couples, half of whom lack an explanation for
their delay in conceiving. Developments in the diagnosis and treatment of subfertility over …

[HTML][HTML] Molecular control of rodent spermatogenesis

SZ Jan, G Hamer, S Repping, DG de Rooij… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Spermatogenesis is a complex developmental process that ultimately generates mature
spermatozoa. This process involves a phase of proliferative expansion, meiosis, and …

[HTML][HTML] Towards a multi-omics of male infertility

AO Wagner, A Turk, T Kunej - The world journal of men's health, 2023 - ncbi.nlm.nih.gov
Infertility is a common problem affecting one in six couples and in 30% of infertile couples,
the male factor is a major cause. A large number of genes are involved in spermatogenesis …

Incorrect DNA methylation of the DAZL promoter CpG island associates with defective human sperm

P Navarro-Costa, P Nogueira, M Carvalho… - Human …, 2010 - academic.oup.com
BACKGROUND Successful gametogenesis requires the establishment of an appropriate
epigenetic state in developing germ cells. Nevertheless, an association between abnormal …

Male hypogonadism: an extended classification based on a developmental, endocrine physiology‐based approach

RA Rey, RP Grinspon, S Gottlieb, T Pasqualini… - …, 2013 - Wiley Online Library
Normal testicular physiology results from the integrated function of the tubular and interstitial
compartments. Serum markers of interstitial tissue function are testosterone and insulin‐like …

Spermatogonial stem cell autotransplantation and germline genomic editing: a future cure for spermatogenic failure and prevention of transmission of genomic …

CL Mulder, Y Zheng, SZ Jan, RB Struijk… - Human …, 2016 - academic.oup.com
BACKGROUND Subfertility affects approximately 15% of all couples, and a severe male
factor is identified in 17% of these couples. While the etiology of a severe male factor …

RFX2 is a major transcriptional regulator of spermiogenesis

WS Kistler, D Baas, S Lemeille, M Paschaki… - PLoS …, 2015 - journals.plos.org
Spermatogenesis consists broadly of three phases: proliferation of diploid germ cells,
meiosis, and finally extensive differentiation of the haploid cells into effective delivery …

Genetics of male infertility

JM Hotaling - Urologic Clinics, 2014 - urologic.theclinics.com
Approximately 1 in 6 couples in the Western world is not able to conceive spontaneously
after 1 year of unprotected intercourse; in nearly half of these couples, the male partner has …

Altered microRNA profiles of testicular biopsies from patients with nonobstructive azoospermia

HT Zhang, Z Zhang, K Hong, WH Tang… - Asian journal of …, 2020 - journals.lww.com
Many studies have shown that microRNAs (miRNAs) play vital roles during the
spermatogenesis. However, little is known about the altered miRNA profiles of testicular …

Mediterranean diet and the risk of poor semen quality: cross‐sectional analysis of men referring to an Italian Fertility Clinic

E Ricci, F Bravi, S Noli, S Ferrari, V De Cosmi… - …, 2019 - Wiley Online Library
Background Several diet patterns have been suggested as involved in processes of
spermatogenesis and thus in male subfertility. To study the relation between Mediterranean …