Chronic inflammation generated by the tumor microenvironment is known to drive cancer
initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor …

Inflammatory cytokines are highly inducible small glycoproteins or regulatory proteins of low
molecular weight secreted by different cell types. They regulate intercellular communication …

Prostate cancer represents a substantial clinical challenge because it is difficult to predict
outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 …

The androgen receptor (AR), ligand-induced transcription factor, is expressed in primary
prostate cancer and in metastases. AR regulates multiple cellular events, proliferation …

The androgen receptor (AR) signaling axis plays a critical role in the development, function
and homeostasis of the prostate. The classical action of AR is to regulate gene …

Down‐regulation of microRNA‐26a (miR‐26a) is associated with poor prognosis of
hepatocellular carcinoma (HCC), but its functional mechanism in HCC remains unclear. In …

Abstract Context Prostate cancer (PCa) is a clinically heterogeneous disease with marked
variability in patient outcomes. Molecular characterization has revealed striking mutational …

Background and objectives Obesity is associated with metabolic dysfunction and over
nutrition. Increased body mass index and obesity are strongly amalgamated with changes in …

Androgen deprivation therapy (ADT) is considered as the standard therapy for men with de
novo or recurrent metastatic prostate cancer. ADT commonly leads to initial biochemical and …

Constitutive NF-κB activation by proinflammatory cytokines plays a major role in cancer
progression. However, the underlying mechanism is still unclear. We report here that histone …