RNA interference in Histoplasma capsulatum demonstrates a role for α‐(1,3)‐glucan in virulence
CA Rappleye, JT Engle, WE Goldman - Molecular microbiology, 2004 - Wiley Online Library
Histoplasma capsulatum is a fungal pathogen that causes respiratory and systemic disease
by proliferating within macrophages. While much is known about histoplasmosis, only a …
by proliferating within macrophages. While much is known about histoplasmosis, only a …
Aspects of fungal pathogenesis in humans
JAH van Burik, PT Magee - Annual Reviews in Microbiology, 2001 - annualreviews.org
▪ Abstract Fungal diseases have become increasingly important in the past few years.
Because few fungi are professional pathogens, fungal pathogenic mechanisms tend to be …
Because few fungi are professional pathogens, fungal pathogenic mechanisms tend to be …
Extracellular Superoxide Dismutase Protects Histoplasma Yeast Cells from Host-Derived Oxidative Stress
BH Youseff, ED Holbrook, KA Smolnycki… - PLoS …, 2012 - journals.plos.org
In order to establish infections within the mammalian host, pathogens must protect
themselves against toxic reactive oxygen species produced by phagocytes of the immune …
themselves against toxic reactive oxygen species produced by phagocytes of the immune …
Pathogenicity & virulence of Histoplasma capsulatum - A multifaceted organism adapted to intracellular environments
Histoplasmosis is a systemic mycosis caused by the thermally dimorphic fungus
Histoplasma capsulatum. Although healthy individuals can develop histoplasmosis, the …
Histoplasma capsulatum. Although healthy individuals can develop histoplasmosis, the …
Temperature-induced switch to the pathogenic yeast form of Histoplasma capsulatum requires Ryp1, a conserved transcriptional regulator
VQ Nguyen, A Sil - Proceedings of the National Academy of …, 2008 - National Acad Sciences
Histoplasma capsulatum, a fungal pathogen of humans, switches from a filamentous spore-
forming mold in the soil to a pathogenic budding-yeast form in the human host. This …
forming mold in the soil to a pathogenic budding-yeast form in the human host. This …
Genome Diversity, Recombination, and Virulence across the Major Lineages of Paracoccidioides
The Paracoccidioides genus includes two species of thermally dimorphic fungi that cause
paracoccidioidomycosis, a neglected health-threatening human systemic mycosis endemic …
paracoccidioidomycosis, a neglected health-threatening human systemic mycosis endemic …
A silver bullet in a golden age of functional genomics: the impact of Agrobacterium-mediated transformation of fungi
The implementation of Agrobacterium tumefaciens as a transformation tool revolutionized
approaches to discover and understand gene functions in a large number of fungal species …
approaches to discover and understand gene functions in a large number of fungal species …
Calcium sequestration by fungal melanin inhibits calcium–calmodulin signalling to prevent LC3-associated phagocytosis
I Kyrmizi, H Ferreira, A Carvalho, JAL Figueroa… - Nature …, 2018 - nature.com
Abstract LC3-associated phagocytosis (LAP) is a non-canonical autophagy pathway
regulated by Rubicon, with an emerging role in immune homeostasis and antifungal host …
regulated by Rubicon, with an emerging role in immune homeostasis and antifungal host …
Thermally dimorphic human fungal pathogens—polyphyletic pathogens with a convergent pathogenicity trait
A Sil, A Andrianopoulos - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Fungi are adept at changing their cell shape and developmental program in response to
signals in their surroundings. Here we focus on a group of evolutionarily related fungal …
signals in their surroundings. Here we focus on a group of evolutionarily related fungal …
Fungal dimorphism and virulence: molecular mechanisms for temperature adaptation, immune evasion, and in vivo survival
GM Gauthier - Mediators of inflammation, 2017 - Wiley Online Library
The thermally dimorphic fungi are a unique group of fungi within the Ascomycota phylum
that respond to shifts in temperature by converting between hyphae (22–25° C) and yeast …
that respond to shifts in temperature by converting between hyphae (22–25° C) and yeast …