This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …

The advantages of the model organism Drosophila melanogaster, including low genetic
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …

Studies of neuropeptide and peptide hormone signaling are coming of age in Drosophila
due to rapid developments in molecular genetics approaches that overcome the difficulties …

An intrinsic clock enables an organism to anticipate environmental changes and use energy
sources more efficiently, thereby conferring an adaptive advantage. Having an intrinsic clock …

Circadian clocks organize behavior and physiology to adapt to daily environmental cycles.
Genetic approaches in the fruit fly, Drosophila melanogaster, have revealed widely …

Though much is known about the cellular and molecular components of the circadian clock,
output pathways that couple clock cells to overt behaviors have not been identified. We …

Circadian timekeeping in mammals is driven by transcriptional/posttranslational feedback
loops [1] that are active within both peripheral tissues and the circadian pacemaker of the …

Neuropeptides modulate neural circuits controlling adaptive animal behaviors and
physiological processes, such as feeding/metabolism, reproductive behaviors, circadian …

Nowadays humans mainly rely on external, unnatural clocks such as of cell phones and
alarm clocks–driven by circuit boards and electricity. Nevertheless, our body is under the …

The neuropeptide PDF is released by sixteen clock neurons in Drosophila and helps
maintain circadian activity rhythms by coordinating a network of∼ 150 neuronal clocks …