Cell migration is crucial for physiological and pathological processes such as
morphogenesis, wound repair, immune response and cancer invasion/metastasis. There are …

RAS-related C3 botulinum toxin substrate 1 (Rac. 1) is one of the important members of Rho
GTPases. It is well known that Rac1 is a cytoskeleton regulation protein that regulates cell …

Small-cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options.
The dismal prognosis in SCLC is in part associated with an upregulation of BCL-2 family anti …

Triple-negative breast cancer (TNBC) is the most poorly treated subtype of breast cancer,
and targeting the heterogeneity of TNBC has emerged as a fascinating therapeutic strategy …

Overexpression of drug efflux transporters is commonly associated with multidrug-resistance
in cancer therapy. Here for the first time, we investigated the ability of diindolylmethane …

Intervertebral disc degeneration (IDD) is highly ubiquitous in the aged population and is an
essential factor for low back pain and spinal disability. Because of the association between …

Aim: The current investigation is focused on the targeted delivery of doxorubicin through
CD44 aptamer-mediated active targeting to the human breast cancer cells. Methods: CD44 …

CircBRWD3 is a newly discovered circRNA, and its potential function has not been probed.
Here, we aimed to molecularly dissect the role of circBRWD3 in the tumorigenesis and …

Adipocyte-derived leptin activates multiple oncogenic signaling, leading to breast cancer
cell progression and metastasis. Hence, finding effective strategies to inhibit the oncogenic …

Extrachromosomal circular DNAs (eccDNAs) have been proved an inseparable relationship
with cancer, based on the biological mechanisms of its biogenesis and impact on …