Interactions between therapeutics for metabolic disease, cardiovascular risk factors, and gut microbiota

QY Ding, JX Tian, M Li, FM Lian, LH Zhao… - Frontiers in Cellular …, 2020 - frontiersin.org
With improved standards of living, the incidence of multiple metabolic disorders has
increased year by year, especially major risk factors for cardiovascular disease such as …

Unlock the thermogenic potential of adipose tissue: pharmacological modulation and implications for treatment of diabetes and obesity

XR Peng, P Gennemark, G O'Mahony… - Frontiers in …, 2015 - frontiersin.org
Brown adipose tissue (BAT) is considered an interesting target organ for the treatment of
metabolic disease due to its high metabolic capacity. Non-shivering thermogenesis, once …

[HTML][HTML] N-acetyl-L-cysteine treatment reduces beta-cell oxidative stress and pancreatic stellate cell activity in a high fat diet-induced diabetic mouse model

M Schuurman, M Wallace, G Sahi, M Barillaro… - Frontiers in …, 2022 - frontiersin.org
Obesity plays a major role in type II diabetes (T2DM) progression because it applies
metabolic and oxidative stress resulting in dysfunctional beta-cells and activation of intra …

Electronic health records and community health surveillance of childhood obesity

TL Flood, YQ Zhao, EJ Tomayko, A Tandias… - American journal of …, 2015 - Elsevier
Background Childhood obesity remains a public health concern, and tracking local progress
may require local surveillance systems. Electronic health record data may provide a cost …

[HTML][HTML] Obesity pharmacotherapy in patients with type 2 diabetes

S Kahan, K Fujioka - Diabetes Spectrum: a Publication of the …, 2017 - ncbi.nlm.nih.gov
IN BRIEF Patients with obesity and type 2 diabetes are key targets for weight loss. Given the
lack of behavioral weight loss in most patients, obesity pharmacotherapy options should be …

Impact of adherence and weight loss on glycemic control in patients with type 2 diabetes: cohort analyses of integrated medical record, pharmacy claims, and patient …

C McAdam-Marx, BK Bellows, S Unni, G Wygant… - Journal of Managed …, 2014 - jmcp.org
BACKGROUND: Managed care organizations put great effort into managing the population
of patients with type 2 diabetes mellitus (T2DM) because of the health and economic burden …

Determinants of glycaemic control in a practice setting: the role of weight loss and treatment adherence (The DELTA Study)

C McAdam‐Marx, BK Bellows, S Unni… - … journal of clinical …, 2014 - Wiley Online Library
Aims Examine the association between weight loss and adherence with glycaemic goal
attainment in patients with inadequately controlled T2 DM. Materials and methods Patients≥ …

Comparative effectiveness of adding alogliptin to metformin plus sulfonylurea with other DPP-4 inhibitors in type 2 diabetes: a systematic review and network meta …

S Kay, A Strickson, J Puelles, R Selby, E Benson… - Diabetes Therapy, 2017 - Springer
Introduction Alogliptin is an oral antihyperglycemic agent that is a selective inhibitor of the
enzyme dipeptidyl peptidase-4 (DPP-4), approved for the treatment of type 2 diabetes …

Real‐world weight change among patients treated with glucagon‐like peptide‐1 receptor agonist, dipeptidyl peptidase‐4 inhibitor and sulfonylureas for type 2 …

GS Carls, R Tan, JY Zhu, E Tuttle, J Yee… - Obesity Science & …, 2017 - Wiley Online Library
Aims The study aims to examine real‐world weight change and the role of medication
adherence among patients with type 2 diabetes who initiated one of three drug classes …

Provider beliefs about diabetes treatment have little impact on glycemic control of their patients with diabetes

ES LeBlanc, AG Rosales, S Kachroo… - BMJ Open Diabetes …, 2015 - drc.bmj.com
Objective To improve the health of people with diabetes, it is essential to identify why
patients experience extended periods of poor glycemic control before therapeutic …