Heparanase—A single protein with multiple enzymatic and nonenzymatic functions
I Vlodavsky, Y Kayal, M Hilwi, S Soboh… - Proteoglycan …, 2023 - Wiley Online Library
Heparanase (Hpa1) is expressed by tumor cells and cells of the tumor microenvironment
and functions extracellularly to remodel the extracellular matrix (ECM) and regulate the …
and functions extracellularly to remodel the extracellular matrix (ECM) and regulate the …
[HTML][HTML] Heparanase 2 (Hpa2)-a new player essential for pancreatic acinar cell differentiation
Y Kayal, U Barash, I Naroditsky, N Ilan… - Cell Death & …, 2023 - nature.com
Abstract Heparanase 2 (Hpa2, HPSE2) is a close homolog of heparanase. Hpa2, however,
lacks intrinsic heparan sulfate (HS)-degrading activity, the hallmark of heparanase …
lacks intrinsic heparan sulfate (HS)-degrading activity, the hallmark of heparanase …
[HTML][HTML] Nuclear localization of heparanase 2 (Hpa2) attenuates breast carcinoma growth and metastasis
M Hilwi, K Shulman, I Naroditsky, S Feld… - Cell Death & …, 2024 - nature.com
Unlike the intense research effort devoted to exploring the significance of heparanase in
cancer, very little attention was given to Hpa2, a close homolog of heparanase. Here, we …
cancer, very little attention was given to Hpa2, a close homolog of heparanase. Here, we …
Impact of heparanase‐2 (Hpa2) on cancer and inflammation: Advances and paradigms
I Vlodavsky, M Hilwi, Y Kayal, S Soboh… - The FASEB …, 2024 - Wiley Online Library
HPSE2, the gene‐encoding heparanase 2 (Hpa2), is mutated in urofacial syndrome (UFS),
a rare autosomal recessive congenital disease attributed to peripheral neuropathy. Hpa2 …
a rare autosomal recessive congenital disease attributed to peripheral neuropathy. Hpa2 …
[HTML][HTML] Effect of HPSE and HPSE2 SNPs on the Risk of Developing Primary Paraskeletal Multiple Myeloma
O Ostrovsky, K Beider, H Magen, M Leiba… - Cells, 2023 - mdpi.com
Multiple myeloma (MM) is a plasma cell malignancy that is accompanied by hypercalcemia,
renal failure, anemia, and lytic bone lesions. Heparanase (HPSE) plays an important role in …
renal failure, anemia, and lytic bone lesions. Heparanase (HPSE) plays an important role in …