Novel antiviral agents: Synthesis, molecular modelling studies and biological investigation

S Brogi - Viruses, 2023 - mdpi.com
Representing more than 20% of all deaths occurring worldwide, infectious diseases remain
one of the main factors in both human and animal morbidity and mortality. Approximately …

Small Molecules Incorporating Privileged Amidine Moiety as Potential Hits Combating Antibiotic-Resistant Bacteria

SM El-Sayed, SA Ahmed, K Gulia, JR Lenhard… - Pharmaceuticals, 2023 - mdpi.com
The continuing need for the discovery of potent antibacterial agents against antibiotic-
resistant pathogens is the driving force for many researchers to design and develop such …

Design, Synthesis, In Vitro, and In Silico Studies of New N5-Substituted-pyrazolo[3,4-d]pyrimidinone Derivatives as Anticancer CDK2 Inhibitors

WA Zaki, SM El-Sayed, M Alswah, A El-Morsy… - Pharmaceuticals, 2023 - mdpi.com
CDK2 is a key player in cell cycle processes. It has a crucial role in the progression of
various cancers. Hepatocellular carcinoma (HCC) and colorectal cancer (CRC) are two …