Ectopic expression of a mechanosensitive channel confers spatiotemporal resolution to ultrasound stimulations of neurons for visual restoration

S Cadoni, C Demené, I Alcala, M Provansal… - Nature …, 2023 - nature.com
Remote and precisely controlled activation of the brain is a fundamental challenge in the
development of brain–machine interfaces for neurological treatments. Low-frequency …

Activation of mechanosensitive ion channels by ultrasound

YC Chu, J Lim, A Chien, CC Chen, JL Wang - Ultrasound in medicine & …, 2022 - Elsevier
Mechanosensitive channels (MSCs) play an important role in how cells transduce
mechanical stimuli into electrical or chemical signals, which provides an interventional …

Ultrasonic neuromodulation and sonogenetics: a new era for neural modulation

S Wang, W Meng, Z Ren, B Li, T Zhu, H Chen… - Frontiers in …, 2020 - frontiersin.org
Non-invasive ultrasonic neural modulation (UNM), a non-invasive technique with enhanced
spatial focus compared to conventional electrical neural modulation, has attracted much …

Ultrasonic control of neural activity through activation of the mechanosensitive channel MscL

J Ye, S Tang, L Meng, X Li, X Wen, S Chen, L Niu… - Nano …, 2018 - ACS Publications
Externally controlling the excitation of a neuronal subset through ion channels activation can
modulate the firing pattern of an entire neural circuit in vivo. As nanovalves in the cell …

Mechanosensitive channel-based optical membrane tension reporter

YY Hsu, AM Resto Irizarry, J Fu, AP Liu - ACS sensors, 2023 - ACS Publications
Plasma membrane tension functions as a global physical organizer of cellular activities.
Technical limitations of current membrane tension measurement techniques have hampered …

Sonogenetic control of multiplexed genome regulation and base editing

P Liu, J Foiret, Y Situ, N Zhang, AJ Kare, B Wu… - Nature …, 2023 - nature.com
Manipulating gene expression in the host genome with high precision is crucial for
controlling cellular function and behavior. Here, we present a precise, non-invasive, and …

Vision restoration by optogenetic therapy and developments toward sonogenetic therapy

M Provansal, K Marazova, JA Sahel… - … vision science & …, 2022 - tvst.arvojournals.org
After revolutionizing neuroscience, optogenetic therapy has entered successfully in clinical
trials for restoring vision to blind people with degenerative eye diseases, such as retinitis …

Wireless Force‐Inducing Neuronal Stimulation Mediated by High Magnetic Moment Microdiscs

C Collier, N Muzzio, R Thevi Guntnur… - Advanced …, 2022 - Wiley Online Library
Noninvasive manipulation of cell signaling is critical in basic neuroscience research and in
developing therapies for neurological disorders and psychiatric conditions. Here, the …

Response of heterologously expressed pressure sensor-actuator-modulator macromolecule to external mechanical stress

S Batabyal, C Idigo, D Narcisse, A Dibas, S Mohanty - Heliyon, 2024 - cell.com
Cells from different organs in the body experience a range of mechanical and osmotic
pressures that change in various diseases, including neurological, cardiovascular …

Manipulation of new fluorescent magnetic nanoparticles with an electromagnetic needle, allowed determining the viscosity of the cytoplasm of M-HeLa cells

I Ramazanova, M Suslov, G Sibgatullina, K Petrov… - Pharmaceuticals, 2023 - mdpi.com
Magnetic nanoparticles (MNPs) have recently begun to be actively used in biomedicine
applications, for example, for targeted drug delivery, in tissue engineering, and in magnetic …