[HTML][HTML] Role of CFTR in epithelial physiology
V Saint-Criq, MA Gray - Cellular and Molecular Life Sciences, 2017 - Springer
Salt and fluid absorption and secretion are two processes that are fundamental to epithelial
function and whole body fluid homeostasis, and as such are tightly regulated in epithelial …
function and whole body fluid homeostasis, and as such are tightly regulated in epithelial …
[HTML][HTML] Association of pertussis toxin with severe pertussis disease
Pertussis, caused by respiratory tract infection with the bacterial pathogen Bordetella
pertussis, has long been considered to be a toxin-mediated disease. Bacteria adhere and …
pertussis, has long been considered to be a toxin-mediated disease. Bacteria adhere and …
[HTML][HTML] Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis
J Simonin, E Bille, G Crambert, S Noel, E Dreano… - Scientific reports, 2019 - nature.com
Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance
Regulator (CFTR) protein. Morbidity is mainly due to early airway infection. We hypothesized …
Regulator (CFTR) protein. Morbidity is mainly due to early airway infection. We hypothesized …
[PDF][PDF] Contribution of pertussis toxin to the pathogenesis of pertussis disease
NH Carbonetti - Pathogens and disease, 2015 - academic.oup.com
Pertussis toxin (PT) is a multisubunit protein toxin secreted by Bordetella pertussis, the
bacterial agent of the disease pertussis or whooping cough. PT in detoxified form is a …
bacterial agent of the disease pertussis or whooping cough. PT in detoxified form is a …
[HTML][HTML] Association of gut microbiota composition and function with an aged rat model of senile osteoporosis using 16S rRNA and metagenomic sequencing analysis
S Ma, J Qin, Y Hao, L Fu - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Recently, more interest has been paid to the association between bone mass and gut
microecological dysbiosis. The results of clinical studies comparing gut microbiota (GM) in …
microecological dysbiosis. The results of clinical studies comparing gut microbiota (GM) in …
[HTML][HTML] Inhibition of Pendrin by a small molecule reduces Lipopolysaccharide-induced acute Lung Injury
EH Lee, MH Shin, M Gi, J Park, D Song, YM Hyun… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Pendrin is encoded by SLC26A4 and its mutation leads to congenital hearing
loss. Additionally, pendrin is up-regulated in inflammatory airway diseases such as chronic …
loss. Additionally, pendrin is up-regulated in inflammatory airway diseases such as chronic …
Bordetella pertussis: new concepts in pathogenesis and treatment
NH Carbonetti - Current opinion in infectious diseases, 2016 - journals.lww.com
Bordetella pertussis: new concepts in pathogenesis and treat... : Current Opinion in Infectious
Diseases Bordetella pertussis: new concepts in pathogenesis and treatment : Current Opinion …
Diseases Bordetella pertussis: new concepts in pathogenesis and treatment : Current Opinion …
Pendrin mediates bicarbonate secretion and enhances cystic fibrosis transmembrane conductance regulator function in airway surface epithelia
Bicarbonate facilitates mucin unpacking and bacterial killing; however, its transport
mechanisms in the airways are not well understood. cAMP stimulates anion efflux through …
mechanisms in the airways are not well understood. cAMP stimulates anion efflux through …
Fatal pertussis in the neonatal mouse model is associated with pertussis toxin-mediated pathology beyond the airways
KM Scanlon, YG Snyder, C Skerry… - Infection and …, 2017 - Am Soc Microbiol
In infants, Bordetella pertussis can cause severe disease, manifested as pronounced
leukocytosis, pulmonary hypertension, and even death. The exact cause of death remains …
leukocytosis, pulmonary hypertension, and even death. The exact cause of death remains …
[HTML][HTML] Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis
PM Haggie, PW Phuan, JA Tan, L Zlock… - The FASEB …, 2016 - ncbi.nlm.nih.gov
Abstract Pendrin (SLC26A4) is a Cl−/anion exchanger expressed in the epithelium of
inflamed airways where it is thought to facilitate Cl− absorption and HCO 3− secretion …
inflamed airways where it is thought to facilitate Cl− absorption and HCO 3− secretion …