Over the past decade, remarkable advances have been witnessed in the development of
small-molecule probes. These molecular tools have been widely applied for interrogating …

Among the major neurodegenerative disorders (NDDs), Alzheimer's disease (AD) and
Parkinson's disease (PD), are a huge socioeconomic burden. Over many centuries, people …

Major depressive disorder (MDD) is considered a serious public health issue that adversely
impacts an individual's quality of life and contributes significantly to the global burden of …

The use of privileged structures in drug discovery has proven to be an effective strategy,
allowing the generation of innovative hits/leads and successful optimization processes …

Fluorescent probes have long been valuable tools in the study of biological systems. With
the ever-expanding range of known enzymatic biomarkers for disease, it has never been …

Rationale Ayahuasca is a psychotropic plant tea from South America used for religious
purposes by indigenous people of the Amazon. Increasing evidence indicates that …

Curcumin is the principal curcuminoid found in turmeric (Curcuma longa), a spice frequently
used in Asian countries. Given its anti-inflammatory and antioxidant properties, it has been …

Targeting tumor-associated macrophages (TAMs) is a promising strategy to modify the
immunosuppressive tumor microenvironment and improve cancer immunotherapy …

Monoamine oxidase (MAO) is believed to mediate the degradation of monoamine
neurotransmitters, including dopamine, in the brain. Between the two types of MAO, MAO-B …

Despite standard hormonal therapy that targets the androgen receptor (AR) attenuates
prostate cancer (PCa) effectively in the initial stage, the tumor ultimately converts to …