Tumor-associated macrophages (TAMs) are major innate immune cells that constitute up to
50% of the cell mass of human tumors. TAMs are highly heterogeneous cells that originate …

Tumor metastasis is a major contributor to the death of cancer patients. It is driven not only
by the intrinsic alterations in tumor cells, but also by the implicated cross-talk between …

Macrophages play an important role in tissue homeostasis, tissue remodeling, immune
response, and progression of cancer. Consequently, macrophages exhibit significant …

CC chemokines, a subfamily of 27 chemotactic cytokines, are a component of intercellular
communication, which is crucial for the functioning of the tumor microenvironment. Although …

The immunosuppressive tumor microenvironment (TME) represents a major barrier for
effective immunotherapy. Tumor-associated macrophages (TAMs) are highly heterogeneous …

Simple Summary Since the targeting of a single pro-angiogenic factor fails to improve
oncological disease outcome, significant efforts have been made to identify new pro …

Colitis-associated colorectal cancer is the most serious complication of ulcerative colitis.
Long-term chronic inflammation increases the incidence of CAC in UC patients. Compared …

The risk of colorectal cancer (CRC) is higher in patients with inflammatory bowel disease
(IBD). Population-based data from patients with ulcerative colitis (UC) estimate that the risk …

Colorectal cancer (CRC) is one of the most devastating diseases that accounts for numerous
deaths worldwide. Tumor cell-autonomous pathways, such as the oncogenic signaling …

Background: Tumor environment has been recognized to affect cancer cell progression,
such as tumor-associated macrophages. However, increasing evidences suggest that tumor …