Aneuploidy in mammalian oocytes and the impact of maternal ageing
C Charalambous, A Webster, M Schuh - Nature Reviews Molecular Cell …, 2023 - nature.com
During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …
each chromosome to the embryo. However, human eggs frequently contain an incorrect …
Single-cell RNA sequencing for the study of development, physiology and disease
SS Potter - Nature Reviews Nephrology, 2018 - nature.com
An ongoing technological revolution is continually improving our ability to carry out very high-
resolution studies of gene expression patterns. Current technology enables the global gene …
resolution studies of gene expression patterns. Current technology enables the global gene …
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays
Spatially resolved transcriptomic technologies are promising tools to study complex
biological processes such as mammalian embryogenesis. However, the imbalance between …
biological processes such as mammalian embryogenesis. However, the imbalance between …
Rolling back human pluripotent stem cells to an eight-cell embryo-like stage
After fertilization, the quiescent zygote experiences a burst of genome activation that initiates
a short-lived totipotent state. Understanding the process of totipotency in human cells would …
a short-lived totipotent state. Understanding the process of totipotency in human cells would …
Mechanism of spindle pole organization and instability in human oocytes
C So, K Menelaou, J Uraji, K Harasimov, AM Steyer… - Science, 2022 - science.org
Human oocytes are prone to assembling meiotic spindles with unstable poles, which can
favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown …
favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown …
Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell
The turnover of the intestinal epithelium is driven by multipotent LGR5+ crypt-base columnar
cells (CBCs) located at the bottom of crypt zones. However, CBCs are lost following injury …
cells (CBCs) located at the bottom of crypt zones. However, CBCs are lost following injury …
[HTML][HTML] Construction of heparin-based hydrogel incorporated with Cu5. 4O ultrasmall nanozymes for wound healing and inflammation inhibition
Y Peng, D He, X Ge, Y Lu, Y Chai, Y Zhang, Z Mao… - Bioactive Materials, 2021 - Elsevier
Excessive production of inflammatory chemokines and reactive oxygen species (ROS) can
cause a feedback cycle of inflammation response that has a negative effect on cutaneous …
cause a feedback cycle of inflammation response that has a negative effect on cutaneous …
[HTML][HTML] 8C-like cells capture the human zygotic genome activation program in vitro
J Taubenschmid-Stowers, M Rostovskaya, F Santos… - Cell stem cell, 2022 - cell.com
The activation of the embryonic genome marks the first major wave of transcription in the
developing organism. Zygotic genome activation (ZGA) in mouse 2-cell embryos and 8-cell …
developing organism. Zygotic genome activation (ZGA) in mouse 2-cell embryos and 8-cell …
Gene co-expression analysis for functional classification and gene–disease predictions
S Van Dam, U Vosa, A van der Graaf… - Briefings in …, 2018 - academic.oup.com
Gene co-expression networks can be used to associate genes of unknown function with
biological processes, to prioritize candidate disease genes or to discern transcriptional …
biological processes, to prioritize candidate disease genes or to discern transcriptional …
Human embryonic genome activation initiates at the one-cell stage
In human embryos, the initiation of transcription (embryonic genome activation [EGA]) occurs
by the eight-cell stage, but its exact timing and profile are unclear. To address this, we …
by the eight-cell stage, but its exact timing and profile are unclear. To address this, we …