Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

Mitochondria are critical for regulation of the activation, differentiation, and survival of
macrophages and other immune cells. In response to various extracellular signals, such as …

The guanosine triphosphatase (GTPase) Rab32 coordinates a cell-intrinsic host defense
mechanism that restricts the replication of intravacuolar pathogens such as Salmonella …

Endogenous small molecules are metabolic regulators of cell function. Itaconate is a key
molecule that accumulates in cells when the Krebs cycle is disrupted. Itaconate is derived …

Mononuclear phagocytes are a widely distributed family of cells contributing to innate and
adaptive immunity. Circulating monocytes and tissue macrophages participate in all stages …

Macrophages are innate immune cells in the organism and can be found in almost tissues
and organs. They are highly plastic and heterogeneous cells and can participate in the …

Background Acute lung injury (ALI) is a fatal disease in the absence of pharmacological
treatment. Oxidative stress and inflammation are closely related to ALI. Innate immune cells …

Background Identifying effective drugs to suppress vascular inflammation is a promising
strategy to delay the progression of abdominal aortic aneurysm (AAA). Itaconate has a vital …

To characterize transcriptomic changes in endothelial cells (ECs) infected by coronaviruses,
and stimulated by DAMPs, the expressions of 1311 innate immune regulatomic genes (IGs) …

Osteoarthritis (OA) and rheumatoid arthritis (RA) are inflammatory articular conditions with
different aetiology, but both result in joint damage. The nutritionally essential metal zinc …