Background. The genetic contribution to longevity in humans has been estimated to range
from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with …

Thirteen common susceptibility loci have been reproducibly associated with cutaneous
malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis …

Research on mechanisms underlying fetal programming of health and disease risk has
focused primarily on processes that are specific to cell types, organs or phenotypes of …

Telomeres are the protective end caps of chromosomes and shorten with every cell division.
Telomere length has been proposed as a biomarker of biological age and a risk factor for …

METHODS: LTL was measured in blood samples from 490 newborns and their parents.
RESULTS: LTL (mean±SD) was longer (9.50±0.70 kb) in newborns than in their mothers …

It is now well established that the genomic landscape of DNA methylation (DNAm) gets
altered as a function of age, a process we here call 'epigenetic drift'. The biological …

Telomeres are tandem repeat DNA sequences present at the ends of each eukaryotic
chromosome to stabilize the genome structure integrity. Telomere lengths progressively …

Epidemiological studies have principally relied on measurements of telomere length (TL) in
leucocytes, which reflects TL in other somatic cells. Leucocyte TL (LTL) displays vast …

Background Telomere shortness in human beings is a prognostic marker of ageing, disease,
and premature morbidity. We previously found an association between 3 months of …

Chronic obstructive pulmonary disease and pulmonary fibrosis have been hypothesized to
represent premature aging phenotypes. At times, they cluster in families, but the genetic …