GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy
L Broer, AS Buchman, J Deelen… - … Series A: Biomedical …, 2015 - academic.oup.com
Background. The genetic contribution to longevity in humans has been estimated to range
from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with …
from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with …
Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
Thirteen common susceptibility loci have been reproducibly associated with cutaneous
malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis …
malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis …
The fetal programming of telomere biology hypothesis: an update
S Entringer, K de Punder, C Buss… - … Transactions of the …, 2018 - royalsocietypublishing.org
Research on mechanisms underlying fetal programming of health and disease risk has
focused primarily on processes that are specific to cell types, organs or phenotypes of …
focused primarily on processes that are specific to cell types, organs or phenotypes of …
Telomere biology and age-related diseases
M Herrmann, I Pusceddu, W März… - Clinical Chemistry and …, 2018 - degruyter.com
Telomeres are the protective end caps of chromosomes and shorten with every cell division.
Telomere length has been proposed as a biomarker of biological age and a risk factor for …
Telomere length has been proposed as a biomarker of biological age and a risk factor for …
Leukocyte telomere length in newborns: implications for the role of telomeres in human disease
METHODS: LTL was measured in blood samples from 490 newborns and their parents.
RESULTS: LTL (mean±SD) was longer (9.50±0.70 kb) in newborns than in their mothers …
RESULTS: LTL (mean±SD) was longer (9.50±0.70 kb) in newborns than in their mothers …
Age-associated epigenetic drift: implications, and a case of epigenetic thrift?
It is now well established that the genomic landscape of DNA methylation (DNAm) gets
altered as a function of age, a process we here call 'epigenetic drift'. The biological …
altered as a function of age, a process we here call 'epigenetic drift'. The biological …
Telomeres and telomerase in cardiovascular diseases
JK Yeh, CY Wang - Genes, 2016 - mdpi.com
Telomeres are tandem repeat DNA sequences present at the ends of each eukaryotic
chromosome to stabilize the genome structure integrity. Telomere lengths progressively …
chromosome to stabilize the genome structure integrity. Telomere lengths progressively …
Reflections on telomere dynamics and ageing-related diseases in humans
A Aviv, JW Shay - … Transactions of the Royal Society B …, 2018 - royalsocietypublishing.org
Epidemiological studies have principally relied on measurements of telomere length (TL) in
leucocytes, which reflects TL in other somatic cells. Leucocyte TL (LTL) displays vast …
leucocytes, which reflects TL in other somatic cells. Leucocyte TL (LTL) displays vast …
Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a …
Background Telomere shortness in human beings is a prognostic marker of ageing, disease,
and premature morbidity. We previously found an association between 3 months of …
and premature morbidity. We previously found an association between 3 months of …
Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis–emphysema
SE Stanley, DL Gable, CL Wagner, TM Carlile… - Science translational …, 2016 - science.org
Chronic obstructive pulmonary disease and pulmonary fibrosis have been hypothesized to
represent premature aging phenotypes. At times, they cluster in families, but the genetic …
represent premature aging phenotypes. At times, they cluster in families, but the genetic …