Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants
Inherited genetic variation influencing leukocyte telomere length provides a natural
experiment for testing associations with health outcomes, more robust to confounding and …
experiment for testing associations with health outcomes, more robust to confounding and …
A genome-wide association study yields five novel thyroid cancer risk loci
J Gudmundsson, G Thorleifsson, JK Sigurdsson… - Nature …, 2017 - nature.com
The great majority of thyroid cancers are of the non-medullary type. Here we report findings
from a genome-wide association study of non-medullary thyroid cancer, including in total …
from a genome-wide association study of non-medullary thyroid cancer, including in total …
A null mutation in SERPINE1 protects against biological aging in humans
SS Khan, SJ Shah, E Klyachko, AS Baldridge… - Science …, 2017 - science.org
Plasminogen activator inhibitor–1 (PAI-1) has been shown to be a key component of the
senescence-related secretome and a direct mediator of cellular senescence. In murine …
senescence-related secretome and a direct mediator of cellular senescence. In murine …
Stress, telomeres, and psychopathology: toward a deeper understanding of a triad of early aging
ES Epel, AA Prather - Annual review of clinical psychology, 2018 - annualreviews.org
Telomeres play an important part in aging and show relationships to lifetime adversity,
particularly childhood adversity. Meta-analyses demonstrate reliable associations between …
particularly childhood adversity. Meta-analyses demonstrate reliable associations between …
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk
KM Walsh, V Codd, IV Smirnov, T Rice, PA Decker… - Nature …, 2014 - nature.com
Glioma, the most common central nervous system cancer in adults, has poor prognosis.
Here we identify a new SNP associated with glioma risk, rs1920116 (near TERC), that …
Here we identify a new SNP associated with glioma risk, rs1920116 (near TERC), that …
Genetic susceptibility to chronic kidney disease–some more pieces for the heritability puzzle
M Cañadas-Garre, K Anderson, R Cappa… - Frontiers in …, 2019 - frontiersin.org
Chronic kidney disease (CKD) is a major global health problem with an increasing
prevalence partly driven by aging population structure. Both genomic and environmental …
prevalence partly driven by aging population structure. Both genomic and environmental …
Telomerase as a therapeutic target in cardiovascular disease
J Hoffmann, G Richardson, J Haendeler… - … and Vascular Biology, 2021 - Am Heart Assoc
Shortened telomeres have been linked to numerous chronic diseases, most importantly
coronary artery disease, but the underlying mechanisms remain ill defined. Loss-of-function …
coronary artery disease, but the underlying mechanisms remain ill defined. Loss-of-function …
Telomere length loss due to smoking and metabolic traits
J Huzen, LSM Wong… - Journal of internal …, 2014 - Wiley Online Library
Objectives Human age‐dependent telomere attrition and telomere shortening are
associated with several age‐associated diseases and poorer overall survival. The aim of …
associated with several age‐associated diseases and poorer overall survival. The aim of …
Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources
Recent work has linked psychological stress with premature cellular aging as indexed by
reduced leukocyte telomere length. The combination of shorter telomeres with high …
reduced leukocyte telomere length. The combination of shorter telomeres with high …
Efficacy of meaning-centered group psychotherapy for cancer survivors: a randomized controlled trial
N Van der Spek, J Vos, CF van Uden-Kraan… - Psychological …, 2017 - cambridge.org
BackgroundThe aim of this study was to assess the efficacy of meaning-centered group
psychotherapy for cancer survivors (MCGP-CS) to improve personal meaning, compared …
psychotherapy for cancer survivors (MCGP-CS) to improve personal meaning, compared …