Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants

CL Kuo, LC Pilling, GA Kuchel, L Ferrucci… - Aging cell, 2019 - Wiley Online Library
Inherited genetic variation influencing leukocyte telomere length provides a natural
experiment for testing associations with health outcomes, more robust to confounding and …

A genome-wide association study yields five novel thyroid cancer risk loci

J Gudmundsson, G Thorleifsson, JK Sigurdsson… - Nature …, 2017 - nature.com
The great majority of thyroid cancers are of the non-medullary type. Here we report findings
from a genome-wide association study of non-medullary thyroid cancer, including in total …

A null mutation in SERPINE1 protects against biological aging in humans

SS Khan, SJ Shah, E Klyachko, AS Baldridge… - Science …, 2017 - science.org
Plasminogen activator inhibitor–1 (PAI-1) has been shown to be a key component of the
senescence-related secretome and a direct mediator of cellular senescence. In murine …

Stress, telomeres, and psychopathology: toward a deeper understanding of a triad of early aging

ES Epel, AA Prather - Annual review of clinical psychology, 2018 - annualreviews.org
Telomeres play an important part in aging and show relationships to lifetime adversity,
particularly childhood adversity. Meta-analyses demonstrate reliable associations between …

Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk

KM Walsh, V Codd, IV Smirnov, T Rice, PA Decker… - Nature …, 2014 - nature.com
Glioma, the most common central nervous system cancer in adults, has poor prognosis.
Here we identify a new SNP associated with glioma risk, rs1920116 (near TERC), that …

Genetic susceptibility to chronic kidney disease–some more pieces for the heritability puzzle

M Cañadas-Garre, K Anderson, R Cappa… - Frontiers in …, 2019 - frontiersin.org
Chronic kidney disease (CKD) is a major global health problem with an increasing
prevalence partly driven by aging population structure. Both genomic and environmental …

Telomerase as a therapeutic target in cardiovascular disease

J Hoffmann, G Richardson, J Haendeler… - … and Vascular Biology, 2021 - Am Heart Assoc
Shortened telomeres have been linked to numerous chronic diseases, most importantly
coronary artery disease, but the underlying mechanisms remain ill defined. Loss-of-function …

Telomere length loss due to smoking and metabolic traits

J Huzen, LSM Wong… - Journal of internal …, 2014 - Wiley Online Library
Objectives Human age‐dependent telomere attrition and telomere shortening are
associated with several age‐associated diseases and poorer overall survival. The aim of …

Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources

A Zalli, LA Carvalho, J Lin, M Hamer… - Proceedings of the …, 2014 - National Acad Sciences
Recent work has linked psychological stress with premature cellular aging as indexed by
reduced leukocyte telomere length. The combination of shorter telomeres with high …

Efficacy of meaning-centered group psychotherapy for cancer survivors: a randomized controlled trial

N Van der Spek, J Vos, CF van Uden-Kraan… - Psychological …, 2017 - cambridge.org
BackgroundThe aim of this study was to assess the efficacy of meaning-centered group
psychotherapy for cancer survivors (MCGP-CS) to improve personal meaning, compared …