Macrophage function in adipose tissue homeostasis and metabolic inflammation
Obesity-related metabolic organ inflammation contributes to cardiometabolic disorders. In
obese individuals, changes in lipid fluxes and storage elicit immune responses in the …
obese individuals, changes in lipid fluxes and storage elicit immune responses in the …
Metabolic inflammation and insulin resistance in obesity
H Wu, CM Ballantyne - Circulation research, 2020 - Am Heart Assoc
Obesity is becoming an epidemic in the United States and worldwide and increases risk for
many diseases, particularly insulin resistance, type 2 diabetes mellitus, and cardiovascular …
many diseases, particularly insulin resistance, type 2 diabetes mellitus, and cardiovascular …
Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes
Obesity is one of the major health burdens of the 21st century as it contributes to the growing
prevalence of its related comorbidities, including insulin resistance and type 2 diabetes …
prevalence of its related comorbidities, including insulin resistance and type 2 diabetes …
Obese visceral fat tissue inflammation: from protective to detrimental?
H Kolb - BMC medicine, 2022 - Springer
Obesity usually is accompanied by inflammation of fat tissue, with a prominent role of
visceral fat. Chronic inflammation in obese fat tissue is of a lower grade than acute immune …
visceral fat. Chronic inflammation in obese fat tissue is of a lower grade than acute immune …
[HTML][HTML] Mechanisms of insulin action and insulin resistance
MC Petersen, GI Shulman - Physiological reviews, 2018 - journals.physiology.org
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …
research into insulin action and resistance has issued. In the intervening century, some …
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
L Ferrucci, E Fabbri - Nature Reviews Cardiology, 2018 - nature.com
Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …
Chronic tissue inflammation and metabolic disease
YS Lee, J Olefsky - Genes & development, 2021 - genesdev.cshlp.org
Obesity is the most common cause of insulin resistance, and the current obesity epidemic is
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …
The PI3K/Akt pathway in meta-inflammation
M Acosta-Martinez, MZ Cabail - International journal of molecular …, 2022 - mdpi.com
Obesity is a global epidemic representing a serious public health burden as it is a major risk
factor for the development of cardiovascular disease, stroke and all-cause mortality. Chronic …
factor for the development of cardiovascular disease, stroke and all-cause mortality. Chronic …
An integrated view of immunometabolism
YS Lee, J Wollam, JM Olefsky - Cell, 2018 - cell.com
The worldwide obesity epidemic has emerged as a major cause of insulin resistance and
Type 2 diabetes. Chronic tissue inflammation is a well-recognized feature of obesity, and the …
Type 2 diabetes. Chronic tissue inflammation is a well-recognized feature of obesity, and the …
The role of ceramides in insulin resistance
E Sokolowska, A Blachnio-Zabielska - Frontiers in Endocrinology, 2019 - frontiersin.org
Resistance to insulin is a pathophysiological state related to the decreased response of
peripheral tissues to the insulin action, hyperinsulinemia and raised blood glucose levels …
peripheral tissues to the insulin action, hyperinsulinemia and raised blood glucose levels …