Ovarian cancer is the most frequent cause of deaths from among gynecologic malignancies.
Due to its asymptomatic development the disease is frequently diagnosed at an advanced …

High-grade serous carcinoma (HGSC) is the most prevalent and aggressive subtype of
ovarian cancer. The large degree of clinical heterogeneity within HGSC has justified …

Ovarian cancer (OC) is a heterogeneous disease usually diagnosed at a late stage.
Experimental in vitro models that faithfully capture the hallmarks and tumor heterogeneity of …

Specific micro RNA s (mi RNA s) are packaged in exosomes that regulate processes in
tumor development and progression. The current study focuses on the influence of …

Germline pathogenic mutations in BReast CAncer (BRCA1) genes are thought to drive
normal fallopian tube epithelial (FTE) cell transformation to high-grade serous ovarian …

Our understanding of the molecular determinants of cancer is still inadequate because of
cancer heterogeneity. Here, using epithelial ovarian cancer (EOC) as a model system, we …

A key feature of high-grade serous ovarian carcinoma (HGSOC) is frequent amplification of
the 3q26 locus harboring PRKC-ι (PRKCI). Here, we show that PRKCI is also expressed in …

The fallopian tube epithelium (FTE) has been recognized as a site of origin of high-grade
serous ovarian cancer (HGSC). However, the absence of relevant in vitro human models …

Owing to technical advances in single-cell biology, the appreciation of cellular heterogeneity
has increased, which has aided our understanding of organ function, homeostasis, and …

Improving screening and treatment options for patients with epithelial ovarian cancer has
been a major challenge in cancer research. Development of novel diagnostic and …