Administration through the respiratory tract can be advantageous, with high drug
bioavailability, limited enzymatic activity, reduced dose requirements compared to oral, and …

Background: The digital twin as an integrated technology has been widely used in the
medical field. Currently, the application of digital twin technology in the field of respiratory …

Respiratory diseases are a leading cause of disability and death worldwide. Several of the
most prevalent respiratory diseases are associated with smoking, including chronic …

Respiratory diseases are a leading cause of death worldwide. Despite modern medicine,
treatment of lung diseases is limited by the tools available to diagnose these disorders …

ABSTRACT RNA therapeutics are promising for the treatment of lung diseases where small
molecules and biologics have failed to have much success in the past. While siRNA and …

Exposure science has developed alongside epidemiology and toxicology as a field that
aims to describe qualitatively and, in particular, quantitatively the contact of an individual or …

In recent years, there has been a concerted effort to develop in vivo and ex vivo models that
replicate the histology, physiology, and pathology of human airways, but their translation to …

The bronchial tree reconstruction is a challenging task due to its non-uniform topological
boundaries and asymmetric branching pattern. Contrary to the conventional approaches of …

Orally inhaled drug products (OIDPs) refer to a drug-device system in which drugs in the
form of aerosols, powders, solutions, or suspensions are delivered into the lung via oral …

Background Tracheal stents can be placed in a narrow position in the human trachea to
ensure smooth breathing. And the stent will deform during service by the influence of the …