Fetus Exposure to Drugs and Chemicals: A Holistic Overview on the Assessment of Their Transport and Metabolism across the Human Placental Barrier
I Kotta-Loizou, A Pritsa, G Antasouras, SN Vasilopoulos… - Diseases, 2024 - mdpi.com
Background: The placenta exerts a crucial role in fetus growth and development during
gestation, protecting the fetus from maternal drugs and chemical exposure. However …
gestation, protecting the fetus from maternal drugs and chemical exposure. However …
PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses
M Le Merdy, KX Szeto, J Perrier, MB Bolger… - Pharmaceutics, 2024 - mdpi.com
This study aimed to develop a physiologically based pharmacokinetic (PBPK) model that
simulates metabolically cleared compounds' pharmacokinetics (PK) in pregnant subjects …
simulates metabolically cleared compounds' pharmacokinetics (PK) in pregnant subjects …
[HTML][HTML] Factors contributing to variability in metformin concentration in polycystic ovary syndrome
VN Nikolić, M Stefanović, D Mitić, S Sunarić… - Croatian Medical …, 2024 - ncbi.nlm.nih.gov
Aim To investigate the factors affecting metformin concentrations after chronic administration
in patients with polycystic ovary syndrome (PCOS), focusing on the pharmacokinetic …
in patients with polycystic ovary syndrome (PCOS), focusing on the pharmacokinetic …