Obesity and type 2 diabetes mellitus (T2DM) are increasing in prevalence owing to
decreases in physical activity levels and a shift to diets that include addictive and/or high …

The gut harbors an enormous diversity of microbes that are essential for the maintenance of
homeostasis in health and disease. A growing body of evidence supports the role of this …

The tongue is a complex multifunctional organ that interacts and senses both interoceptively
and exteroceptively. Although it is easily visible to almost all of us, it is relatively …

Tuft cells are found in tissues with distinct stem cell compartments, tissue architecture, and
luminal exposures but converge on a shared transcriptional program, including expression …

Despite evidence that the ability to taste is weakened by obesity and can be rescued with
weight loss intervention, few studies have investigated the molecular effects of obesity on …

The discovery of IL-10 more than 30 years ago marked the beginning of our understanding
of how cytokines regulate immune responses, based on cross-regulation between Th1 and …

Gut microbiota has emerged as a major metabolically active organ with critical functions in
both health and disease. The trillions of microorganisms hosted by the gastrointestinal tract …

The oral microbiome is second only to its intestinal counterpart in diversity and abundance,
but its effects on taste cells remains largely unexplored. Using single-cell RNASeq, we found …

Abstract Analysis of single-cell RNA-Seq data can provide insights into the specific functions
of individual cell types that compose complex tissues. Here, we examined gene expression …

Inflammatory cytokines are important regulators of metabolism and food intake. Over
production of inflammatory cytokines during bacterial and viral infections leads to anorexia …