The consensus on the monitoring, treatment, and prevention of leukemia relapse after allogeneic hematopoietic stem cell transplantation in China

Y Wang, H Chen, J Chen, M Han, JD Hu, J Hu… - Cancer Letters, 2018 - Elsevier
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important curative
therapy for patients with leukemia. However, relapse remains the leading cause of death …

A practical guide to chimerism analysis: review of the literature and testing practices worldwide

AG Blouin, F Ye, J Williams, M Askar - Human immunology, 2021 - Elsevier
Abstract Background and Purpose Currently there are no widely accepted guidelines for
chimerism analysis testing in hematopoietic cell transplantation (HCT) patients. The …

Chimerism analysis for clinicians: a review of the literature and worldwide practices

AG Blouin, M Askar - Bone marrow transplantation, 2022 - nature.com
This review highlights literature pertinent to chimerism analysis in the context of
hematopoietic cell transplantation (HCT). We also conducted a survey of testing practices of …

Donor and host coexpressing KIR ligands promote NK education after allogeneic hematopoietic stem cell transplantation

XY Zhao, XX Yu, ZL Xu, XH Cao, MR Huo… - Blood …, 2019 - ashpublications.org
The rate and extent of natural killer (NK)–cell education after hematopoietic cell
transplantation correlates with leukemia control. To study the effect of donor and host HLA …

Expanded clinical‐grade membrane‐bound IL‐21/4‐1BBL NK cell products exhibit activity against acute myeloid leukemia in vivo

XY Zhao, Q Jiang, H Jiang, LJ Hu… - European Journal of …, 2020 - Wiley Online Library
Background Adoptive NK cell infusion is a promising immunotherapy for acute myeloid
leukemia (AML) patients. The aim of this study was to test the activity of clinical‐grade …

How I treat measurable (minimal) residual disease in acute leukemia after allogeneic hematopoietic cell transplantation

A Spyridonidis - Blood, The Journal of the American Society of …, 2020 - ashpublications.org
Although allogeneic hematopoietic cell transplantation (allo-HCT) is currently the standard
curative treatment of acute leukemia, relapse remains unacceptably high. Measurable …

[HTML][HTML] Clinical utility of quantitative PCR for chimerism and engraftment monitoring after allogeneic stem cell transplantation for hematologic malignancies

M Ahci, K Stempelmann, U Buttkereit, P Crivello… - Biology of Blood and …, 2017 - Elsevier
Although quantitative PCR (qPCR) has been explored for chimerism monitoring after
allogeneic stem cell transplantation (SCT), evidence regarding its clinical utility compared …

Current trends in applications of circulatory microchimerism detection in transplantation

H Andrikovics, Z Őrfi, N Meggyesi, A Bors… - International Journal of …, 2019 - mdpi.com
Primarily due to recent advances of detection techniques, microchimerism (the proportion of
minor variant population is below 1%) has recently gained increasing attention in the field of …

[HTML][HTML] Allogeneic hematopoietic cell transplantation in multiple myeloma: focus on longitudinal assessment of donor chimerism, extramedullary disease, and high …

L Rasche, C Röllig, G Stuhler, S Danhof… - Biology of Blood and …, 2016 - Elsevier
Although generally not applied as first-line treatment of multiple myeloma, allogeneic
hematopoietic cell transplantation (allo-SCT) can still be chosen as ultimate escalation …

Ultrasensitive chimerism enhances measurable residual disease testing after allogeneic hematopoietic cell transplantation

SB Kanaan, F Urselli, JP Radich, JL Nelson - Blood Advances, 2023 - ashpublications.org
Increasing mixed chimerism (reemerging recipient cells) after allogeneic hematopoietic cell
transplant (allo-HCT) can indicate relapse, the leading factor determining mortality in blood …