Nucleic acids are an attractive platform for organizing molecular self-assembly because of
their specific nucleobase interactions and defined length scale. Routinely employed in the …

Peptide nucleic acids (PNAs) can target and stimulate recombination reactions in genomic
DNA. We have reported that γPNA oligomers possessing the diethylene glycol γ-substituent …

New polyanionic modifications of polyamide nucleic acid mimics were obtained. Thymine
decamers were synthesized from respective chiral α-and γ-monomers, and their …

A PNA molecule is a DNA strand where the sugar-phosphate backbone has been replaced
by a structurally homomorphous pseudopeptide chain consisting of N (2-amino-ethyl) …

The introductory section of the review will contain the description of a relatively new class of
artificial biopolymers–polyamide nucleic acid (PNA) mimics. Their characteristic structural …

A method for the synthesis of 6-O-benzyl-and 6-O-benzyl-2-N-benzyloxycarbonyl-protected
guanine derivatives starting from 2-amino-6-chloropurin is described. A regioselective …

Peptide Nucleic Acids (PNAs) are nanostructures similar to nucleic acid molecules (synthetic
DNA/RNA analogs) wherein the negatively charged backbone (sugar-phosphate) present in …

Currently, peptide nucleic acids (PNAs) play an important role as therapeuticAhmed S.
Abdelbaky1, 2,*, Ivan A. Prokhorov1, Elena V. Gnuskova1, Olga V. Esipova1 and Yulia G …

One of the major challenges facing modern biochemical and biomedical technologies are
finding molecular tools for diagnosis and detection of genetic diseases. In this connection …

Изобретение относится к области биоорганической химии, фармакологии,
молекулярной биологии и может быть использовано для получения терапевтически …