Neurotropism of SARS-CoV-2 and neurological diseases of the central nervous system in COVID-19 patients

S Veleri - Experimental brain research, 2022 - Springer
The devastating COVID-19 pandemic is caused by the SARS-CoV-2 virus. It primarily affects
the lung and induces acute respiratory distress leading to a decrease in oxygen supply to …

Long-term effects of SARS-CoV-2 in the brain: clinical consequences and molecular mechanisms

AC Granholm - Journal of Clinical Medicine, 2023 - mdpi.com
Numerous investigations have demonstrated significant and long-lasting neurological
manifestations of COVID-19. It has been suggested that as many as four out of five patients …

Neuroinflammation after COVID-19 with persistent depressive and cognitive symptoms

J Braga, M Lepra, SJ Kish, PM Rusjan, Z Nasser… - JAMA …, 2023 - jamanetwork.com
Importance Persistent depressive symptoms, often accompanied by cognitive symptoms,
commonly occur after COVID-19 illness (hereinafter termedCOVID-DC, DC for depressive …

SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties

MG Frank, KH Nguyen, JB Ball, S Hopkins… - Brain, Behavior, and …, 2022 - Elsevier
SARS-CoV-2 infection produces neuroinflammation as well as neurological, cognitive (ie,
brain fog), and neuropsychiatric symptoms (eg, depression, anxiety), which can persist for …

Mechanisms of coronavirus infectious disease 2019-related neurologic diseases

RS Klein - Current opinion in neurology, 2022 - journals.lww.com
Mechanisms of coronavirus infectious disease 2019-related ne... : Current Opinion in
Neurology Mechanisms of coronavirus infectious disease 2019-related neurologic diseases …

[HTML][HTML] SARS-CoV-2 and multiple sclerosis: potential for disease exacerbation

M MacDougall, J El-Hajj Sleiman… - Frontiers in …, 2022 - frontiersin.org
While the respiratory tract is the primary route of entry for SARS-CoV-2, evidence shows that
the virus also impacts the central nervous system. Intriguingly, case reports have …

SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction

C Hirunpattarasilp, G James, J Kwanthongdee… - Brain, 2023 - academic.oup.com
Abstract The SARS-CoV-2 receptor, ACE2, is found on pericytes, contractile cells
enwrapping capillaries that regulate brain, heart and kidney blood flow. ACE2 converts …

Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vaping

Y Zhang, SR Archie, Y Ghanwatkar, S Sharma… - Fluids and Barriers of …, 2022 - Springer
Background Knowledge of the entry receptors responsible for SARS-CoV-2 is key to
understand the neural transmission and pathogenesis of COVID-19 characterized by a …

Central nervous system pericytes contribute to health and disease

F Girolamo, M Errede, A Bizzoca, D Virgintino, D Ribatti - Cells, 2022 - mdpi.com
Successful neuroprotection is only possible with contemporary microvascular protection.
The prevention of disease-induced vascular modifications that accelerate brain damage …

Repeated ethanol exposure and withdrawal alters angiotensin‐converting enzyme 2 expression in discrete brain regions: Implications for SARS‐CoV‐2 …

N Balasubramanian, TD James… - Alcohol: Clinical and …, 2023 - Wiley Online Library
Background People with alcohol use disorder (AUD) may be at higher risk for COVID‐19.
Angiotensin‐converting enzyme 2 (ACE2) and transmembrane serine protease 2 …