Angiotensin‐converting enzyme 2 (ACE2), a key enzyme in the renin–angiotensin system
(RAS), is expressed in various tissues and organs, including the central nervous system …

Abstract The coronavirus disease 2019 (COVID-19) pandemic is responsible for 267 million
infections and over 5 million deaths globally. COVID-19 is caused by severe acute …

Abstract The SARS-CoV-2 spike S1 subunit (S1) can cross the blood–brain barrier and elicit
neuroinflammatory response independent of viral infection. Here we examined whether S1 …

Coronaviruses are prevalent in mammals and birds, including humans and bats, and they
often spread through airborne droplets. In humans, these droplets then interact with …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the novel global
coronavirus disease 2019 (COVID-19) disease outbreak. Its pathogenesis is mostly located …

Simple Summary We analyzed the underlying mechanism of thyroidal manifestations in
patients with COVID-19 using ACE2 and TMPRSS2 immunostaining. Prior to our work, few …

The expression of ACE2 is linked to disease severity in COVID-19 patients. The ACE2
receptor gene polymorphisms are considered determinants for SARS-CoV-2 infection and …

Anxiety and depression are prevalent mental disorders around the world. The etiology of
both diseases is multifactorial, involving biological and psychological issues. The COVID-19 …

An imbalance in the circulatory and organ-specific renin-angiotensin system (RAS)
pathways is associated with age-related dysfunction and disease including cardiovascular …

Neuroinflammation and oxidative stress contribute to the progression of sepsis-associated
encephalopathy (SAE). Angiotensin-converting enzyme 2 (ACE2) is considered to be a …