Overdose deaths are often viewed as the leading edge of the opioid epidemic which has
gripped the United States over the past two decades (Skolnick, 2018a). This emphasis is …

Fentanyl is a powerful opioid anesthetic and analgesic, the use of which has caused an
increasing public health threat in the United States and elsewhere. Fentanyl was initially …

Synthetic opioids constitute one of the fastest-growing groups of new psychoactive
substances (NPS) worldwide. With fentanyl analogues being increasingly controlled via …

Heroin is an opioid agonist commonly abused for its rewarding effects. Since its synthesis at
the end of the nineteenth century, its popularity as a recreational drug has ebbed and …

In December 2018, the Centers for Disease Control declared fentanyl the deadliest drug in
America. Opioid overdose is the single greatest cause of death in the United States adult …

Background The emergence of novel synthetic opioids (NSOs) is contributing to the opioid
overdose crisis. While fentanyl analogs have historically dominated the NSO market, a shift …

Recent trends of opioid abuse and related fatalities have highlighted the critical role of Novel
Synthetic Opioids (NSOs). We studied the μ-opioid-like properties of isotonitazene (ITZ) …

Abstract Rationale Novel synthetic opioids (NSOs) are emerging in recreational drug
markets worldwide. In particular, 2-benzylbenzimidazole 'nitazene'compounds are …

The term 'opioids' refers to both the natural compounds ('opiates') which are extracted from
the opium poppy plant (Papaver somniferum) and their semi-synthetic and synthetic …

The recreational use of opioid drugs is a global threat to public health and safety. In
particular, an epidemic of opioid overdose fatalities is being driven by illicitly manufactured …