There is increasing recognition of the crucial role of the right ventricle (RV) in determining
functional status and prognosis in multiple conditions. The normal RV is anatomically and …

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, progressive pulmonary
vascular disease that is usually a consequence of prior acute pulmonary embolism. CTEPH …

Background: Right ventricular (RV) adaptation to acute and chronic pulmonary hypertensive
syndromes is a significant determinant of short-and long-term outcomes. Although …

Survival in patients with pulmonary arterial hypertension (PAH) is closely related to right
ventricular (RV) function. Although pulmonary load is an important determinant of RV …

Pulmonary hypertension (PH) describes heterogeneous population of patients with a mean
pulmonary arterial pressure> 20 mm Hg. Rarely, PH presents as a primary disorder but is …

Our understanding of, and approach to, pulmonary arterial hypertension has undergone a
paradigm shift in the past decade. Once a condition thought to be dominated by increased …

Severe forms of pulmonary arterial hypertension (PAH) are characterized by various
degrees of remodeling of the pulmonary arterial vessels, which increases the pulmonary …

Ventricular failure manifests in many forms, its underlying physiology ranging from overt left
ventricular (LV) systolic dysfunction to isolated right ventricular (RV) diastolic dysfunction …

High altitude (hypobaric hypoxia) triggers several mechanisms to compensate for the
decrease in oxygen bioavailability. One of them is pulmonary artery vasoconstriction and its …

Numerous molecular abnormalities have been described in pulmonary arterial hypertension
(PAH), complicating the translation of candidate therapies to patients because, typically, 1 …