An insight into novel therapeutic potentials of taxifolin

Y Liu, X Shi, Y Tian, S Zhai, Y Liu, Z Xiong… - Frontiers in …, 2023 - frontiersin.org
Taxifolin is a flavonoid compound, originally isolated from the bark of Douglas fir trees,
which is often found in foods such as onions and olive oil, and is also used in commercial …

Opportunities and challenges in enhancing the bioavailability and bioactivity of dietary flavonoids: A novel delivery system perspective

D Yuan, Y Guo, F Pu, C Yang, X Xiao, H Du, J He, S Lu - Food Chemistry, 2024 - Elsevier
Flavonoids have multiple favorable bioactivities including antioxidant, anti-inflammatory, and
antitumor. Currently, flavonoid-containing dietary supplements are widely tested in clinical …

[HTML][HTML] Babao Dan alleviates gut immune and microbiota disorders while impacting the TLR4/MyD88/NF-кB pathway to attenuate 5-Fluorouracil-induced intestinal …

B Huang, M Gui, H An, J Shen, F Ye, Z Ni… - Biomedicine & …, 2023 - Elsevier
Adjuvant chemotherapy based on 5-fluorouracil (5-FU), such as FOLFOX, is suggested as a
treatment for gastrointestinal cancer. Yet, intestinal damage continues to be a prevalent side …

Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin

WL Sun, S Hua, XY Li, L Shen, H Wu, HF Ji - Nature Communications, 2023 - nature.com
Silymarin has been used for improving hepatic damage and lipid disorders, but its action
mechanism remains to be clarified. Here, we investigate the contributions of the gut …

Antibacterial, anti-inflammatory, rapid hemostasis, and accelerated repair by multifunctional metal–organic frameworks fibrous scaffolds for diabetic wounds

N Wang, W Liu, G Chai, S Sun, Q Ding, Z Cheng… - Chemical Engineering …, 2023 - Elsevier
Excessive inflammation, bacterial infection, persistent bleeding, and wound exudate
accumulation are common in diabetic wounds, impeding cell proliferation and disturbing …

The crude guava polysaccharides ameliorate high-fat diet-induced obesity in mice via reshaping gut microbiota

Y Li, D Bai, Y Lu, J Chen, H Yang, Y Mu, J Xu… - International Journal of …, 2022 - Elsevier
Guava is a popular fruit consumed worldwide with beneficial effects in regulation of glucose
and lipid metabolism. Although polysaccharides are a major phytochemical component of …

Taxifolin‐mediated Nrf2 activation ameliorates oxidative stress and apoptosis for the treatment of glucocorticoid‐induced osteonecrosis of the femoral head

H Jiang, C Lin, T Cai, L Jiang, C Lou, S Lin… - Phytotherapy …, 2024 - Wiley Online Library
Glucocorticoid‐induced osteonecrosis of the femoral head (GIONFH) is the main
complication secondary to long‐term or excessive use of glucocorticoids (GCs). Taxifolin …

Taxifolin prevents cisplatin nephrotoxicity by modulating Nrf2/HO-1 pathway and mitigating oxidative stress and inflammation in mice

AA Alanezi, AF Almuqati, MA Alfwuaires, F Alasmari… - Pharmaceuticals, 2022 - mdpi.com
Cisplatin (CIS) is an effective chemotherapeutic agent used in the treatment of several
malignancies. The clinical use of CIS is associated with adverse effects, including acute …

Lonicera japonica polysaccharides alleviate D-galactose-induced oxidative stress and restore gut microbiota in ICR mice

W Sun, J Zhu, G Qin, Y Huang, S Cheng, Z Chen… - International Journal of …, 2023 - Elsevier
Lonicera japonica polysaccharides (LJPs) exhibit anti-aging effect in nematodes. Here, we
further studied the function of LJPs on aging-related disorders in D-galactose (D-gal) …

Propionic Acid Driven by the Lactobacillus johnsonii Culture Supernatant Alleviates Colitis by Inhibiting M1 Macrophage Polarization by Modulating the MAPK …

Z Wu, J He, Z Zhang, J Li, H Zou, X Tan… - Journal of Agricultural …, 2023 - ACS Publications
In this study, we investigated the effects of Lactobacillus johnsonii on the mouse colitis
model. The results showed that the supernatant of the L. johnsonii culture alleviated colitis …