Precision medicine in the clinical management of cancer may be achieved through the
diagnostic platform called “liquid biopsy”. This method utilizes the detection of biomarkers in …

Detection of somatic mutations holds great potential in cancer treatment and has been a
very active research field in the past few years, especially since the breakthrough of the next …

Background Sample index cross-talk can result in false positive calls when massively
parallel sequencing (MPS) is used for sensitive applications such as low-frequency somatic …

Clonal evolution of osimertinib-resistance mechanisms in EGFR mutant lung
adenocarcinoma is poorly understood. Using multi-region whole-exome and RNA …

The rationale for early detection of ovarian cancer is compelling. Ovarian cancer confined to
the ovaries (stage I) can be cured in up to 90% of patients, and disease confined to the …

Bam-readcount is a utility for generating low-level information about sequencing data at
specific nucleotide positions. Originally designed to help filter genomic mutation calls, the …

Ovarian cancer (OC) is characterized by silent progression and late-stage diagnosis. It is
critical to detect and accurately diagnose the disease early to improve survival rates. Tumor …

Several patient-derived tumor models emerged recently as robust preclinical drug-testing
platforms. However, their potential to guide clinical therapy remained unclear. Here, we …

Molecular profiling of tumor biopsies plays an increasingly important role not only in cancer
research, but also in the clinical management of cancer patients. Multi-omics approaches …

Immuno-oncology is an ever growing field that has seen important progress across the
spectrum of cancers. Responses can be deep and durable. However, as only a minority of …