The oral microbiome and the immunobiology of periodontal disease and caries
M Costalonga, MC Herzberg - Immunology letters, 2014 - Elsevier
The composition of the oral microbiome differs from one intraoral site to another, reflecting in
part the host response and immune capacity at each site. By focusing on two major oral …
part the host response and immune capacity at each site. By focusing on two major oral …
Breaking bad: Manipulation of the host response by Porphyromonas gingivalis
G Hajishengallis, RJ Lamont - European journal of immunology, 2014 - Wiley Online Library
Recent metagenomic and mechanistic studies are consistent with a new model of
periodontal pathogenesis. This model proposes that periodontal disease is initiated by a …
periodontal pathogenesis. This model proposes that periodontal disease is initiated by a …
TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk
J Brown, H Wang, GN Hajishengallis… - Journal of dental …, 2011 - journals.sagepub.com
Toll-like receptors play a critical role in innate immunity by detecting invading pathogens.
The ability of TLRs to engage different intracellular signaling molecules and cross-talk with …
The ability of TLRs to engage different intracellular signaling molecules and cross-talk with …
“Gum Bug, Leave My Heart Alone!”—Epidemiologic and Mechanistic Evidence Linking Periodontal Infections and Atherosclerosis
M Kebschull, RT Demmer… - Journal of dental …, 2010 - journals.sagepub.com
Evidence from epidemiologic studies suggests that periodontal infections are independently
associated with subclinical and clinical atherosclerotic vascular disease. Although the …
associated with subclinical and clinical atherosclerotic vascular disease. Although the …
Leukocyte integrins: role in leukocyte recruitment and as therapeutic targets in inflammatory disease
Infection or sterile inflammation triggers site-specific attraction of leukocytes. Leukocyte
recruitment is a process comprising several steps orchestrated by adhesion molecules …
recruitment is a process comprising several steps orchestrated by adhesion molecules …
Microbial manipulation of receptor crosstalk in innate immunity
G Hajishengallis, JD Lambris - Nature Reviews Immunology, 2011 - nature.com
In the arms race of host–microbe co-evolution, successful microbial pathogens have evolved
ingenious ways to evade host immune responses. In this Review, we focus on'crosstalk …
ingenious ways to evade host immune responses. In this Review, we focus on'crosstalk …
The use of rodent models to investigate host–bacteria interactions related to periodontal diseases
DT Graves, D Fine, YTA Teng… - Journal of clinical …, 2008 - Wiley Online Library
Even though animal models have limitations, they are often superior to in vitro or clinical
studies in addressing mechanistic questions and serve as an essential link between …
studies in addressing mechanistic questions and serve as an essential link between …
Porphyromonas gingivalis disturbs host–commensal homeostasis by changing complement function
I Olsen, JD Lambris, G Hajishengallis - Journal of oral …, 2017 - Taylor & Francis
Porphyromonas gingivalis is a Gram-negative anaerobic rod that has been proposed as an
orchestrator of complement-dependent dysbiotic inflammation. This notion was suggested …
orchestrator of complement-dependent dysbiotic inflammation. This notion was suggested …
Crosstalk pathways between Toll-like receptors and the complement system
G Hajishengallis, JD Lambris - Trends in immunology, 2010 - cell.com
The Toll-like receptors (TLRs) and complement are key innate defense systems that are
triggered rapidly upon infection. Although both systems have been investigated primarily as …
triggered rapidly upon infection. Although both systems have been investigated primarily as …
Beyond RGD: virus interactions with integrins
Viruses successfully infect host cells by initially binding to the surfaces of the cells, followed
by an intricate entry process. As multifunctional heterodimeric cell-surface receptor …
by an intricate entry process. As multifunctional heterodimeric cell-surface receptor …