Comparative features and outcomes between paediatric T-cell and B-cell acute lymphoblastic leukaemia

DT Teachey, CH Pui - The Lancet Oncology, 2019 - thelancet.com
Contemporary paediatric clinical trials have improved 5-year event-free survival above 85%
and 5-year overall survival above 90% in B-cell acute lymphoblastic leukaemia (ALL) in …

[HTML][HTML] Precision medicine in acute lymphoblastic leukemia

CH Pui - Frontiers of medicine, 2020 - Springer
The cure rate of childhood acute lymphoblastic leukemia (ALL) has exceeded 90% in some
contemporary clinical trials. However, the dose intensity of conventional chemotherapy has …

Somatic and germline genomics in paediatric acute lymphoblastic leukaemia

CH Pui, KE Nichols, JJ Yang - Nature reviews Clinical oncology, 2019 - nature.com
Advances in genomic research and risk-directed therapy have led to improvements in the
long-term survival and quality of life outcomes of patients with childhood acute lymphoblastic …

Efficacy of tyrosine kinase inhibitors in Ph-like acute lymphoblastic leukemia harboring ABL-class rearrangements

I Tanasi, I Ba, N Sirvent, T Braun… - Blood, The Journal …, 2019 - ashpublications.org
Efficacy of tyrosine kinase inhibitors in Ph-like acute lymphoblastic leukemia harboring ABL-class
rearrangements | Blood | American Society of Hematology Skip to Main Content Advertisement …

Chemotherapy or allogeneic transplantation in high-risk Philadelphia chromosome–negative adult lymphoblastic leukemia

JM Ribera, M Morgades, J Ciudad… - Blood, The Journal …, 2021 - ashpublications.org
The need for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in adults with
Philadelphia chromosome–negative (Ph−) acute lymphoblastic leukemia (ALL) with high …

Global efforts toward the cure of childhood acute lymphoblastic leukaemia

CH Pui, JJ Yang, N Bhakta… - The Lancet Child & …, 2018 - thelancet.com
Improvements in risk-directed treatment and supportive care, together with increased
reliance on both national and international collaborative studies, have made childhood …

Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities

B Burkhardt, ML Hermiston - British Journal of Haematology, 2019 - Wiley Online Library
Lymphoblastic lymphoma (LBL) is the second most common type of Non‐Hodgkin
Lymphoma (NHL) in childhood and adolescence, accounting for 25–35% of all cases. The …

Acute lymphoblastic leukemia in adolescent and young adults: treat as adults or as children?

N Boissel, A Baruchel - Blood, The Journal of the American …, 2018 - ashpublications.org
Adolescent and young adult (AYA) patients with acute lymphoblastic leukemia (ALL) are
recognized as a unique population with specific characteristics and needs. In adolescents …

[HTML][HTML] The journey to CAR T cell therapy: the pediatric and young adult experience with relapsed or refractory B-ALL

G Hucks, SR Rheingold - Blood cancer journal, 2019 - nature.com
Outcomes of pediatric and young adult patients diagnosed with acute lymphoblastic
leukemia (ALL) have improved significantly in the past few decades. Treatment advances …

Outcome of children with hypodiploid acute lymphoblastic leukemia: a retrospective multinational study

CH Pui, P Rebora, M Schrappe… - Journal of Clinical …, 2019 - ascopubs.org
PURPOSE We determined the prognostic factors and utility of allogeneic hematopoietic cell
transplantation among children with newly diagnosed hypodiploid acute lymphoblastic …