The drug discovery process is a rocky path that is full of challenges, with the result that very
few candidates progress from hit compound to a commercially available product, often due …

Microtubules play a crucial role in multiple cellular functions including mitosis, cell signaling,
and organelle trafficking, which makes the microtubule an important target for cancer …

The concept of bioisosterism and the implementation of bioisosteric replacement is
fundamental to medicinal chemistry. The exploration of bioisosteres is often used to probe …

Infectious diseases resulting from various strains of pathogenic bacteria are among the
leading causes of death and morbidity worldwide. The currently-available antibacterial …

Chemotherapy using natural compounds, such as resveratrol, curcumin, paclitaxel,
docetaxel, etoposide, doxorubicin, and camptothecin, is of importance in cancer therapy …

Ethnopharmacological relevance Evodia rutaecarpa, a well-known herb medicine in China,
is extensively applied in traditional Chinese medicine (TCM). The plant has the effects of …

Covering: 2011 to 2021 Trifluoromethyl (CF3)-modified natural products have attracted
increasing interest due to their magical effect in binding affinity and/or drug metabolism and …

Abstract Introduction Natural products (NPs) play a crucial role in the development of
therapeutic drugs. However, it is still highly challenging to identify the targets of NPs …

It is a well-known phenomenon that natural products can serve as powerful drug leads to
generate new molecular entities with novel therapeutic utility. Evodiamine (Evo), a major …

Cancer has been the second heath killer being next only to cardiovascular diseases in
human society. Although many efforts have been taken for cancer therapy and many …