[HTML][HTML] Navigating drug repurposing for Chagas disease: advances, challenges, and opportunities

EOJ Porta, K Kalesh, PG Steel - Frontiers in Pharmacology, 2023 - frontiersin.org
Chagas disease is a vector-borne illness caused by the protozoan parasite Trypanosoma
cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions …

Antiprotozoal compounds from Mikania periplocifolia (Asteraceae)

LC Laurella, OG Elso, RN Rodriguez, JM Viecenz… - Fitoterapia, 2023 - Elsevier
Chagas disease, African trypanosomiasis and Leishmaniasis are neglected parasitic
diseases which affect millions of people worldwide. In a previous work, we report the …

Andrographolide: A Diterpenoid from Cymbopogon schoenanthus Identified as a New Hit Compound against Trypanosoma cruzi Using Machine Learning and …

H Barbosa, GZ Espinoza, M Amaral… - Journal of Chemical …, 2023 - ACS Publications
American Trypanosomiasis, also known as Chagas disease, is caused by the protozoan
Trypanosoma cruzi and exhibits limited options for treatment. Natural products offer various …

Trypanocidal and Anti-Inflammatory Effects of Three ent-Kaurane Diterpenoids from Gymnocoronis spilanthoides var. subcordata (Asteraceae)

MG Selener, J Borgo, MB Sarratea, MA Delfino… - Pharmaceutics, 2024 - mdpi.com
Chagas disease, caused by the protozoan Trypanosoma cruzi, affects 6–7 million people
worldwide. The dichloromethane extract obtained from the aerial parts of Gymnocoronis …

[HTML][HTML] Antiamoebic activities of flavonoids against pathogenic free-living amoebae, Naegleria fowleri and Acanthamoeba species

HG Lê, TC Võ, JM Kang, TH Nguyễn… - Parasites, Hosts and …, 2023 - ncbi.nlm.nih.gov
Free-living amoebae (FLA) rarely cause human infections but can invoke fatal infections in
the central nervous system (CNS). No consensus treatment has been established for FLA …

Anacardic Acid Mixture: Utilization of a Byproduct for the Sustainable Development of a Potential Antichagasic Agent Against Trypanosoma cruzi

TR Nogueira, IM Figueredo, JHS Luciano… - Revista Brasileira de …, 2023 - Springer
The work presents an optimization of the extraction and purification processes of the
anacardic acids mixture and its evaluation as a potential antichagasic drug. The purified …

OPEN ACCESS EDITED BY

A Talevi, EF Cunha-Junior, J Bastida… - The Evolution in …, 2024 - books.google.com
OPEN ACCESS EDITED BY Page 44 TYPE Review frontiers Frontiers in Pharmacology
PUBLISHED 27 July 2023 DOI 10.3389/fphar. 2023.1233253 Check for updates OPEN …

[引用][C] Recent Advances in the Discovery of Antiparasitic Drugs for Chagas Disease and Malaria

J de Moraes - Current Topics in Medicinal Chemistry, 2023 - ingentaconnect.com
Parasitic diseases are responsible for significant morbidity and mortality in tropical and
subtropical countries, especially in poor and marginalized communities, with limited access …

[引用][C] Recent Advances in Drug Discovery for Parasitic Diseases

J de Moraes - Current Topics in Medicinal Chemistry, 2023 - ingentaconnect.com
Parasitic diseases affect more than 1 billion people globally, particularly in the poorest
communities [1]. These diseases are associated with significant morbidity and are a public …