DNA damage, largely owing to oxidative stress, is a leading cause of defective sperm
function. High levels of oxidative stress result in damage to sperm DNA, RNA transcripts …

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …

Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

BACKGROUND Regulated cell death is a fundamental component of numerous
physiological processes; spanning from organogenesis in utero, to normal cell turnover …

Oogenesis is a complex process regulated by a vast number of intra-and extra-ovarian
factors. Oogonia, which originate from primordial germ cells, proliferate by mitosis and form …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

Activation of caspase, externalization of phosphatidyl serine, change in the mitochondrial
membrane potential, and DNA fragmentation are apoptosis markers found in human …

Accurate estimation of the number of ovarian follicles at various stages of development is an
important indicator of the process of folliculogenesis in relation to the endocrine signals and …

Cellular apoptosis appears to be a constant feature in the adult testis and during early
development. This is essential because mammalian spermatogenesis is a complex process …

One of the most powerful tools that the molecular biology revolution has given us is the
ability to turn genes on and off at our discretion. In the mouse, this has been accomplished …