[HTML][HTML] Targeting inflammation in atherosclerosis—from experimental insights to the clinic

O Soehnlein, P Libby - Nature reviews Drug discovery, 2021 - nature.com
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …

[HTML][HTML] Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

How the immune system shapes atherosclerosis: roles of innate and adaptive immunity

P Roy, M Orecchioni, K Ley - Nature Reviews Immunology, 2022 - nature.com
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …

[HTML][HTML] The biology of TREM receptors

M Colonna - Nature Reviews Immunology, 2023 - nature.com
Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis

TP Fidler, C Xue, M Yalcinkaya, B Hardaway… - Nature, 2021 - nature.com
Clonal haematopoiesis, which is highly prevalent in older individuals, arises from somatic
mutations that endow a proliferative advantage to haematopoietic cells. Clonal …

Inflammation during the life cycle of the atherosclerotic plaque

P Libby - Cardiovascular Research, 2021 - academic.oup.com
Inflammation orchestrates each stage of the life cycle of atherosclerotic plaques. Indeed,
inflammatory mediators likely link many traditional and emerging risk factors with …

Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production

M Orecchioni, K Kobiyama, H Winkels, Y Ghosheh… - Science, 2022 - science.org
Atherosclerosis is an inflammatory disease of the artery walls and involves immune cells
such as macrophages. Olfactory receptors (OLFRs) are G protein–coupled chemoreceptors …

Inflammation in atherosclerosis—no longer a theory

P Libby - Clinical chemistry, 2021 - academic.oup.com
Background Inflammation links to atherosclerosis and its complications in various
experimental investigations. Animal studies have implicated numerous inflammatory …

Fate and state of vascular smooth muscle cells in atherosclerosis

JM Miano, EA Fisher, MW Majesky - Circulation, 2021 - Am Heart Assoc
Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic
modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing …

Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression

JW Williams, K Zaitsev, KW Kim, S Ivanov… - Nature …, 2020 - nature.com
Early atherosclerosis depends upon responses by immune cells resident in the intimal aortic
wall. Specifically, the healthy intima is thought to be populated by vascular dendritic cells …