[HTML][HTML] Targeting inflammation in atherosclerosis—from experimental insights to the clinic
O Soehnlein, P Libby - Nature reviews Drug discovery, 2021 - nature.com
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …
inflammation from its inception to the emergence of complications. Targeting inflammatory …
[HTML][HTML] Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?
SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …
formation of plaques containing lipid, connective tissue and immune cells in the intima of …
How the immune system shapes atherosclerosis: roles of innate and adaptive immunity
P Roy, M Orecchioni, K Ley - Nature Reviews Immunology, 2022 - nature.com
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …
preclinical models and emerging evidence in humans have established the crucial roles of …
[HTML][HTML] The biology of TREM receptors
M Colonna - Nature Reviews Immunology, 2023 - nature.com
Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …
The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis
TP Fidler, C Xue, M Yalcinkaya, B Hardaway… - Nature, 2021 - nature.com
Clonal haematopoiesis, which is highly prevalent in older individuals, arises from somatic
mutations that endow a proliferative advantage to haematopoietic cells. Clonal …
mutations that endow a proliferative advantage to haematopoietic cells. Clonal …
Inflammation during the life cycle of the atherosclerotic plaque
P Libby - Cardiovascular Research, 2021 - academic.oup.com
Inflammation orchestrates each stage of the life cycle of atherosclerotic plaques. Indeed,
inflammatory mediators likely link many traditional and emerging risk factors with …
inflammatory mediators likely link many traditional and emerging risk factors with …
Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production
M Orecchioni, K Kobiyama, H Winkels, Y Ghosheh… - Science, 2022 - science.org
Atherosclerosis is an inflammatory disease of the artery walls and involves immune cells
such as macrophages. Olfactory receptors (OLFRs) are G protein–coupled chemoreceptors …
such as macrophages. Olfactory receptors (OLFRs) are G protein–coupled chemoreceptors …
Inflammation in atherosclerosis—no longer a theory
P Libby - Clinical chemistry, 2021 - academic.oup.com
Background Inflammation links to atherosclerosis and its complications in various
experimental investigations. Animal studies have implicated numerous inflammatory …
experimental investigations. Animal studies have implicated numerous inflammatory …
Fate and state of vascular smooth muscle cells in atherosclerosis
Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic
modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing …
modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing …
Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression
Early atherosclerosis depends upon responses by immune cells resident in the intimal aortic
wall. Specifically, the healthy intima is thought to be populated by vascular dendritic cells …
wall. Specifically, the healthy intima is thought to be populated by vascular dendritic cells …