Malaria chemotherapeutics part I: History of antimalarial drug development, currently used therapeutics, and drugs in clinical development

M Schlitzer - ChemMedChem: Chemistry Enabling Drug …, 2007 - Wiley Online Library
Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

Retraction—Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis

MR Mehra, F Ruschitzka, AN Patel - The lancet, 2020 - thelancet.com
several concerns were raised with respect to the veracity of the data and analyses
conducted by Surgisphere Corporation and its founder and our co-author, Sapan Desai, in …

Mechanism of action, resistance, synergism, and clinical implications of azithromycin

M Heidary, A Ebrahimi Samangani… - Journal of Clinical …, 2022 - Wiley Online Library
Background Azithromycin (AZM), sold under the name Zithromax, is classified as a
macrolide. It has many benefits due to its immunomodulatory, anti‐inflammatory, and …

[HTML][HTML] Systematic review and meta-analysis of the effectiveness and safety of hydroxychloroquine in treating COVID-19 patients

TH Yang, CY Chou, YF Yang, CS Chien… - Journal of the …, 2021 - journals.lww.com
Background: Since COVID-19 outbreak, hydroxychloroquine (HCQ) has been tested for
effective therapies, and the relevant researches have shown controversial results. Methods …

Targeting the liver stage of malaria parasites: a yet unmet goal

T Rodrigues, M Prudêncio, R Moreira… - Journal of medicinal …, 2012 - ACS Publications
Malaria remains one of the world's most prevalent tropical diseases because of its high
mortality and morbidity burden, as well as its economic and social impacts on the …

Azithromycin for treating uncomplicated malaria

AM van Eijk, DJ Terlouw - Cochrane database of systematic …, 2011 - cochranelibrary.com
Background To prevent the development of drug resistance, the World Health Organization
(WHO) recommends treating malaria with combination therapy. Azithromycin, an antibiotic …

Intermittent preventive treatment against malaria: an update

RD Gosling, ME Cairns, RM Chico… - Expert review of anti …, 2010 - Taylor & Francis
Intermittent preventive treatment (IPT) against malaria is a malaria control strategy aimed at
reducing the burden of malaria in certain high-risk groups, namely pregnant women and …

Hydroxychloroquine use and progression or prognosis of COVID-19: a systematic review and meta-analysis

Y Zang, X Han, M He, J Shi, Y Li - Naunyn-schmiedeberg's Archives of …, 2021 - Springer
Hydroxychloroquine (HCQ) has been implicated in antiviral activity in vitro against severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, there is still controversy …

Macrolides and associated antibiotics based on similar mechanism of action like lincosamides in malaria

T Gaillard, J Dormoi, M Madamet, B Pradines - Malaria journal, 2016 - Springer
Malaria, a parasite vector-borne disease, is one of the biggest health threats in tropical
regions, despite the availability of malaria chemoprophylaxis. The emergence and rapid …

Azithromycin-chloroquine and the intermittent preventive treatment of malaria in pregnancy

RM Chico, R Pittrof, B Greenwood, D Chandramohan - Malaria journal, 2008 - Springer
In the high malaria-transmission settings of sub-Saharan Africa, malaria in pregnancy is an
important cause of maternal, perinatal and neonatal morbidity. Intermittent preventive …