Sickle cell disease

MJ Bonner, ES Puffer, VW Willard - Textbook of pediatric …, 2010 - books.google.com
Sickle cell disease (SCD) is a group of inherited autosomal recessive disorders, including
sickle cell anemia, sickle beta-thalassemia, and other hemoglobinopathies, which are …

[HTML][HTML] Acute kidney injury in patients treated with immune checkpoint inhibitors

S Gupta, SAP Short, ME Sise, JM Prosek… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Immune checkpoint inhibitor-associated acute kidney injury (ICPi-AKI) has
emerged as an important toxicity among patients with cancer. Methods We collected data on …

Management of the sickle cell trait: an opinion by expert panel members

VM Pinto, L De Franceschi, B Gianesin… - Journal of Clinical …, 2023 - mdpi.com
The number of individuals with the sickle cell trait exceeds 300 million worldwide, making
sickle cell disease one of the most common monogenetic diseases globally. Because of the …

The future of sickle cell disease therapeutics rests in genomics

A Wonkam - Disease models & mechanisms, 2023 - journals.biologists.com
Sickle cell disease (SCD) is the most-common monogenic recessive disease in humans,
annually affecting almost 300,000 newborns worldwide, 75% of whom live in Africa …

Glomerular filtration rate abnormalities in sickle cell disease

N Afangbedji, M Jerebtsova - Frontiers in Medicine, 2022 - frontiersin.org
Sickle cell disease (SCD) is a group of inherited blood disorders affecting the β-globin gene,
resulting in the polymerization of hemoglobin and subsequent sickling of the red blood cell …

Psychiatric comorbidities in adults with sickle cell disease: A narrative review

AD Mishkin, EJ Prince, EJ Leimbach… - British journal of …, 2023 - Wiley Online Library
Although descriptions of quality of life and patient reports of mood in sickle cell disease
(SCD) have become more common in the literature, less is known about psychiatric illness …

Differences in the circulating proteome in individuals with versus without sickle cell trait

Y Cai, N Franceschini, A Surapaneni… - Clinical Journal of the …, 2023 - journals.lww.com
Background: Sickle cell trait affects∼ 8% of African American individuals, along with many
other individuals with ancestry from malaria-endemic regions worldwide. While traditionally …

Proteomic analyses of urinary exosomes identify novel potential biomarkers for early diagnosis of sickle cell nephropathy, a sex-based study

B Packialakshmi, E Limerick, HC Ackerman… - Frontiers in …, 2024 - frontiersin.org
Sickle cell nephropathy (SCN) is a leading cause of morbidity and mortality in sickle cell
disease (SCD). Early intervention is crucial for mitigating its effects. However, current …

Characterizing epigenetic aging in an adult sickle cell disease cohort

BM Le, D Hatch, Q Yang, N Shah, FS Luyster… - Blood …, 2024 - ashpublications.org
Sickle cell disease (SCD) affects∼ 100 000 predominantly African American individuals in
the United States, causing significant cellular damage, increased disease complications …

[HTML][HTML] Sickle cell crisis

MB Borhade, NP Kondamudi - 2018 - europepmc.org
Objectives: Outline the pathophysiology of sickle cell crisis. Review the complications of
sickle cell disease. Outline the treatment and management options available for sickle cell …