Simple Summary Cutaneous melanoma represents the most aggressive form of skin cancer
and its occurrence, development, and progression are based on the accumulation of several …

Melanoma frequently harbors genetic alterations in key molecules leading to the aberrant
activation of PI3K and its downstream pathways. Although the role of PI3K/AKT/mTOR in …

Melanoma clinical outcomes emerge from incompletely understood genetic mechanisms
operating within the tumor and its microenvironment. Here, we used single-cell RNA-based …

Malignant melanoma is a very aggressive skin cancer, characterized by a heterogeneous
nature and high metastatic potential. The incidence of melanoma is continuously increasing …

Melanoma, a highly aggressive skin cancer, is characterized by rapid progression and high
mortality. Recent advances in molecular pathogenesis have shed light on genetic and …

Simple Summary Melanoma is the third most common type of skin cancer. Melanoma is a
heterogeneous tumor, composed of genetically divergent subpopulations. These …

Despite significant advances in targeted therapies against the hyperactivated
BRAFV600/MEK pathway for patients with unresectable metastatic melanoma, acquired …

The second most common mutation in melanoma occurs in NRAS oncogene, being a more
aggressive disease that has no effective approved treatment. Besides, cellular plasticity …

Simple Summary The tumor environment is the place where the tumor resides implying that
it might evolve in the role of disease progression, particularly in the phase of tumor …

Extracellular vesicles (EVs) constitute a vital component of intercellular communication,
exerting significant influence on metastasis formation and drug resistance mechanisms …