Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

Four adenosine receptors have been cloned and characterized from several mammalian
species. The receptors are named adenosine A1, A2A, A2B, and A3. The A2A and A2B …

The class A adenosine A1 receptor (A1R) is a G-protein-coupled receptor that preferentially
couples to inhibitory Gi/o heterotrimeric G proteins, has been implicated in numerous …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Adenosine receptors (ARs) are members of the G protein-coupled receptor family and
mediate the multiple physiological effects of adenosine. Currently, four AR subtypes have …

The ability of the extracellular nucleoside adenosine to regulate metabolism has been
intensively studied since the original description of the cardiovascular effects of adenosine …

The A 2a adenosine receptor is a member of the G-protein coupled receptor family, and its
activation stimulates cyclic AMP production. To determine the residues which are involved in …

Over the past year, mutational analysis of peptide receptors has started to change our
understanding of the interaction between G protein coupled receptors and their ligands, an …

Adenosine produces a wide variety of physiological effects through the activation of cell
surface adenosine receptors (ARs). ARs are members of the G-protein-coupled receptor …

Ever since the discovery of the hypotensive and bradycardiac effects of adenosine,
adenosine receptors continue to represent promising drug targets. First, this is due to the fact …