Abstract In 1994, the “danger model” argued that adaptive immune responses are driven
rather by molecules released upon tissue damage than by the recognition of “strange” …

Among diseases whose cure is still far from being discovered, Alzheimer's disease (AD) has
been recognized as a crucial medical and social problem. A major issue in AD research is …

Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by
inflammation both in peripheral tissues and in hypothalamic areas critical for energy …

Background: Consumption of dietary fat is one of the key factors leading to obesity. High-fat
diet (HFD)-induced obesity is characterized by induction of inflammation in the …

Several neurodegenerative diseases are caused by defects in protein folding, including
Alzheimer, Parkinson, Huntington, and prion diseases. Once a disease-specific protein …

The expansion of the GGGGCC hexanucleotide repeat in the non-coding region of the
Chromosome 9 open-reading frame 72 (C9orf72) gene is the most common genetic cause …

Traumatic brain injury (TBI) induces secondary biochemical changes that contribute to
delayed neuroinflammation, neuronal cell death, and neurological dysfunction. Attenuating …

tRNA (tRNA) is a key molecule used for protein synthesis, with multiple points of stress-
induced regulation that can include transcription, transcript processing, localization and …

A large number of physiologically functional foods are comprised of plant polyphenols. Their
antioxidative activities have been intensively studied for a long period and proposed to be …

As a constitutively active kinase, glycogen synthase kinase 3 (GSK3) is a kinase which
regulates body metabolism by phosphorylation of glycogen synthase (GS) and other …